2265-91-0

Basic information

• Product Name: 1,3-Difluoro-5-iodobenzene
• Synonyms: 1,3-DIFLUORO-5-IODOBENZENE;3,5-DIFLUOROIODOBENZENE;3,5-Difluoroiodobenzene 98%;3,5-Difluoroiodobenzene98%;BENZENE,1,3-DIFLUORO-5-IODO;3-Difluoro-5-iodobenzene
• CAS NO: 2265-91-0
• Molecular Formula: C₆H₃F₂I
• Molecular Weight: 239.99
• EINECS: -0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Aryl;C6;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 2265-91-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 173-174 °C(lit.)
• Flash Point: 180 °F
• Appearance: /
• Density: 2.004
• Vapor Pressure: 1.66mmHg at 25°C
• Refractive Index: n20/D 1.5540(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Light Sensitive
• BRN: 2041185
• CAS DataBase Reference: 1,3-Difluoro-5-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Difluoro-5-iodobenzene(2265-91-0)
• EPA Substance Registry System: 1,3-Difluoro-5-iodobenzene(2265-91-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2265-91-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless or yellow liquid

General Description

3,5-Difluoroiodobenzene is an asymmetric top molecule. 3,5-Difluoroiodobenzene reacts with magnesium turnings in the presence of a minimum amount of ether to afford the corresponding Grignard reagent. This reagent is employed in the synthesis of tris(3,5-difluorophenyl)methanol.

InChI:InChI=1/C6H3F2I/c7-4-1-5(8)3-6(9)2-4/h1-3H

Upstream product

• 461-96-1 3,5-difluorobromobenzene 
• 126261-84-5 1-iodo-4-n-propylbenzene 
• 129714-97-2 3,5-difluorobenzoyl chloride 
• 156545-07-2 3,5-difluorophenylboronic acid 

Downstream Products

• 2969-76-8 1,3-difluoro-9H-fluoren-9-one 
• 2841-37-4 1,3,7-Trifluor-fluorenon 
• 2841-35-2 2-Amino-6.8-difluor-9-oxo-fluoren 
• 913195-06-9 2-(3,5-difluoro-phenyl)-8-methyl-6-phenyl-2H-[2,7]naphthyridine-1-one 
• 1008761-79-2 (+)-(R(p))-2'-(3,5-difluorophenyl)-1,2,3,4,5-pentamethylazaferrocene 
• 1008761-79-2 (-)-(S(p))-2'-(3,5-difluorophenyl)-1,2,3,4,5-pentamethylazaferrocene 
• 1406379-78-9 3-(3,5-difluorophenoxy)benzaldehyde 
• 207462-72-4 3-(3,5-difluorophenyl)propanal 
• 1312936-34-7 C₁₇H₂₁F₂NSi 
• 1393377-87-1 C₂₉H₁₆Br₂F₂O 
• 579-39-5 1,2-bis(4-fluorophenyl)ethane-1,2-dione 
• 1314234-16-6 1,2-bis(3,5-difluorophenyl)acetylene 
• 845823-12-3 1-(3,5-difluorophenyl)-2,2,2-trifluoroethan-1-one 
• 909418-94-6 tert-butyl 4-(3,5-difluorophenyl)piperazine-1-carboxylate 

Relevant articles and documents

Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides

Current methods for functional group interconversion have, for the most part, relied on relatively strong driving forces which often require highly reactive reagents to generate irreversibly a desired product in high yield and selectivity. These approaches generally prevent the use of the same catalytic strategy to perform the reverse reaction. Here we describe a catalytic functional group metathesis approach to interconvert, under CO-free conditions, two synthetically important classes of electrophiles that are often employed in the preparation of pharmaceuticals and agrochemicals—aroyl chlorides (ArCOCl) and aryl iodides (ArI). Our reaction design relies on the implementation of a key reversible ligand C–P bond cleavage event, which enables a non-innocent, metathesis-active phosphine ligand to mediate a rapid aryl group transfer between the two different electrophiles. Beyond enabling a practical and safer approach to the interconversion of ArCOCl and ArI, this type of ligand non-innocence provides a blueprint for the development of a broad range of functional group metathesis reactions employing synthetically relevant aryl electrophiles.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.