207619-48-5Relevant articles and documents
A novel radical cyclization of 2-bromoindoles. Synthesis of hexahydropyrrolo[3,4-b]indoles
Gribble,Fraser,Badenock
, p. 805 - 806 (2001)
Hexahydropyrrolo[3,4-b]indoles 6, 10, and 13 are obtained from 2-bromo-3-carboxamides 5, 9, and 12, respectively, by a 1,5-radical translocation process followed by 5-endo-trig cyclization to the indole C-2 position.
Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group
Nishida, Yuika,Takeda, Norihiko,Matsuno, Kenji,Miyata, Okiko,Ueda, Masafumi
, p. 3928 - 3935 (2018/07/31)
Chloroform-mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the presence of air, the three-component aminocarbonylation reaction proceeded via in-situ generation of phosgene from chloroform and O2 to provide indole-3-carboxamides in a single operation. Application to the synthesis of biologically active compounds and intramolecular acylation are also described.
Synthesis of indole-3-carboxamides via a haloform cleavage reaction of 3-trifluoroacetylindole with lithium dialkylamides
Hassinger, Heidi L.,Soll, Richard M.,Gribble, Gordon W.
, p. 3095 - 3098 (2007/10/03)
Reaction of 3-trifluoroacetylindole (4) with lithium dialkylamides affords the corresponding indole-3-carboxamides (5) in good to excellent yields.