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Chloroform is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

67-66-3 Suppliers

This product is a nationally controlled contraband or patented product, and the Lookchem platform doesn't provide relevant sales information.
  • 67-66-3 Structure
  • Basic information

    1. Product Name: Chloroform
    2. Synonyms: Methyl trichloride;Freon 20;R 20 (refrigerant);Trichloormethaan;Methane trichloride;Cloroformio;Chloroforme;Triclorometano;NCI-C02686;Methenyl trichloride;Methane, trichloro-;Trichlormethan;Trichloroform;Trichloromethane;Methane,trichloro-;Formyl trichloride;Industrial Chloroform;Chloroform, Reagent;Chloroform, Spectrophotometric Grade;
    3. CAS NO:67-66-3
    4. Molecular Formula: CHCl3
    5. Molecular Weight: 119.37764
    6. EINECS: 200-663-8
    7. Product Categories: N/A
    8. Mol File: 67-66-3.mol
    9. Article Data: 284
  • Chemical Properties

    1. Melting Point: -63℃
    2. Boiling Point: 61.2 °C at 760 mmHg
    3. Flash Point: 60.5-61.5°C
    4. Appearance: Colorless liquid
    5. Density: 1.5 g/cm3
    6. Vapor Density: 4.12 (vs air)
    7. Vapor Pressure: 213.3 hPa at 20°C
    8. Refractive Index: 1.444-1.445
    9. Storage Temp.: N/A
    10. Solubility: N/A
    11. Water Solubility: 8 g/L (20℃)
    12. CAS DataBase Reference: Chloroform(CAS DataBase Reference)
    13. NIST Chemistry Reference: Chloroform(67-66-3)
    14. EPA Substance Registry System: Chloroform(67-66-3)
  • Safety Data

    1. Hazard Codes:  Xn:Harmful;
    2. Statements: R22:; R38:; R40:; R48/20/22:;
    3. Safety Statements: S36/37:;
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: III
    8. Hazardous Substances Data: 67-66-3(Hazardous Substances Data)

67-66-3 Usage

Chemical Description

Chloroform is a colorless, heavy, sweet-smelling liquid used as a solvent and in medicine.

Chemical Description

Chloroform is a colorless, sweet-smelling liquid that was once used as an anesthetic.

Chemical Description

Chloroform, ethyl acetate, and petroleum ether are solvents used for extraction and purification.

Chemical Description

Chloroform is a colorless liquid used as a solvent.

Chemical Description

Chloroform is a colorless, sweet-smelling organic compound that is commonly used as a solvent.

Chemical Description

Chloroform, ethanol, and acetic acid are solvents used in the reactions.

Chemical Description

Chloroform is a colorless liquid that was once used as an anesthetic but is now primarily used as a solvent.

Chemical Description

Chloroform is a solvent used in the purification of some compounds, while methanol is a common solvent used in organic chemistry.

Chemical Description

Chloroform and n-hexane are organic solvents used in the study.

Chemical Description

Chloroform is a colorless, sweet-smelling organic compound with the formula CHCl3.

Chemical Description

Chloroform is a colorless, heavy, sweet-smelling liquid used as a solvent and in the production of refrigerants.

Chemical Description

Chloroform is a colorless liquid used as a solvent in various chemical reactions.

Chemical Description

Chloroform is a colorless, sweet-smelling organic compound used as a solvent.

Chemical Description

Chloroform and bromoform are specific examples of haloforms.

Chemical Description

Chloroform is a colorless, sweet-smelling organic compound.

Chemical Description

Chloroform and chloroform-d are solvents, while the other chemicals are aromatic amines or related compounds.

Chemical Description

Chloroform is a colorless, heavy, sweet-smelling liquid used as a solvent.

Chemical Description

Chloroform is used in the TLC solvent system, and aqueous hydrochloric acid is used to form the HC1 salt of the final product.

Chemical Description

Chloroform is a colorless, sweet-smelling organic compound that is used as a solvent.

Chemical Description

Chloroform was used to dilute the mixture, while sodium bisulfite was used as a washing solution.

Check Digit Verification of cas no

The CAS Registry Mumber 67-66-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67-66:
(4*6)+(3*7)+(2*6)+(1*6)=63
63 % 10 = 3
So 67-66-3 is a valid CAS Registry Number.

67-66-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name chloroform

1.2 Other means of identification

Product number -
Other names HCC20

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Volatile organic compounds
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67-66-3 SDS

67-66-3Synthetic route

Bromotrichloromethane
75-62-7

Bromotrichloromethane

N,N,N',N'-Tetraisopropyl-P-methylphosphonous diamide
110838-39-6

N,N,N',N'-Tetraisopropyl-P-methylphosphonous diamide

A

chloroform
67-66-3

chloroform

B

P-(bromomethyl)-N,N,N',N'-tetraisopropylphosphonous diamide
124862-13-1

P-(bromomethyl)-N,N,N',N'-tetraisopropylphosphonous diamide

Conditions
ConditionsYield
In diethyl ether for 0.25h; Ambient temperature;A 100%
B 45%
In diethyl ether for 0.25h; Ambient temperature; or P-ethyl-N,N,N',N'-tetraisopropylphosphonous diamide;A n/a
B 45%
Bromotrichloromethane
75-62-7

Bromotrichloromethane

P-ethyl-N,N,N',N'-tetraisopropylphosphonous diamide
122691-44-5

P-ethyl-N,N,N',N'-tetraisopropylphosphonous diamide

A

chloroform
67-66-3

chloroform

B

P-(1-bromoethyl)-N,N,N',N'-tetraisopropylphosphonous diamide
124862-16-4

P-(1-bromoethyl)-N,N,N',N'-tetraisopropylphosphonous diamide

Conditions
ConditionsYield
In diethyl ether for 0.25h; Ambient temperature;A 100%
B 45%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

isopropylamine
75-31-0

isopropylamine

A

chloroform
67-66-3

chloroform

B

N-Isopropyl-2,2,2-trichloroacetamide
23144-67-4

N-Isopropyl-2,2,2-trichloroacetamide

Conditions
ConditionsYield
In hexaneA n/a
B 100%
pentachloroacetone
1768-31-6

pentachloroacetone

isopropylamine
75-31-0

isopropylamine

A

chloroform
67-66-3

chloroform

B

N-Isopropyl-2,2-dichloroacetamide
39063-24-6

N-Isopropyl-2,2-dichloroacetamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 100%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

N-butylamine
109-73-9

N-butylamine

A

chloroform
67-66-3

chloroform

B

trichloro-acetic acid butylamide
31464-96-7

trichloro-acetic acid butylamide

Conditions
ConditionsYield
In hexaneA n/a
B 100%
pentachloroacetone
1768-31-6

pentachloroacetone

methylamine
74-89-5

methylamine

A

chloroform
67-66-3

chloroform

B

2,2-dichloro-N-methylacetamide
5345-73-3

2,2-dichloro-N-methylacetamide

Conditions
ConditionsYield
In hexane Heating;A n/a
B 100%
1,1,1,3,3-pentachlorobutanone
64697-39-8

1,1,1,3,3-pentachlorobutanone

methylamine
74-89-5

methylamine

A

chloroform
67-66-3

chloroform

B

2,2-Dichloro-N-methyl-propionamide
83703-95-1

2,2-Dichloro-N-methyl-propionamide

Conditions
ConditionsYield
In hexane Heating;A n/a
B 100%
tris(cyclopentadienyl)zirconiumhydride

tris(cyclopentadienyl)zirconiumhydride

A

(π-C5H5)3ZrCl

(π-C5H5)3ZrCl

B

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
With tetrachloromethane In toluene under Ar; excess of CCl4 added to suspension of Cp3ZrH in PhMe; stirredat about 20°C for 5 h; stored overnight at 0-5°C; sepd. by pressure; dried in an Ar stream; elem. anal.;A 99%
B 89%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

2,2,3,3-tetrafluoropropanol
76-37-9

2,2,3,3-tetrafluoropropanol

A

chloroform
67-66-3

chloroform

B

bis(2,2,3,3-tetrafluoropropyl) carbonate
1422-70-4

bis(2,2,3,3-tetrafluoropropyl) carbonate

Conditions
ConditionsYield
With potassium fluoride; zirconium(IV) oxide at 140℃; for 10h; Product distribution / selectivity; pressure tight reactor;A 99%
B 99%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

A

chloroform
67-66-3

chloroform

B

bis(2,2,2-trifluoroethyl) carbonate
1513-87-7

bis(2,2,2-trifluoroethyl) carbonate

Conditions
ConditionsYield
With potassium fluoride; zirconium(IV) oxide at 140℃; for 10h; pressure tight reactor;A 99%
B 99%
N-(2,2,2-trichloroethylidene)benzenesulfonamide
55596-11-7

N-(2,2,2-trichloroethylidene)benzenesulfonamide

complex of sulfur dioxide with dimethylamine
21326-49-8

complex of sulfur dioxide with dimethylamine

A

1,1,2,2-tetrachloroethylene
127-18-4

1,1,2,2-tetrachloroethylene

B

chloroform
67-66-3

chloroform

C

N,N-dimethyl-N′-(phenylsulfonyl)formimidamide
13707-43-2

N,N-dimethyl-N′-(phenylsulfonyl)formimidamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;A n/a
B n/a
C 98%
N-(2,2,2-trichloroethylidene)benzenesulfonamide
55596-11-7

N-(2,2,2-trichloroethylidene)benzenesulfonamide

diethylamine
109-89-7

diethylamine

A

1,1,2,2-tetrachloroethylene
127-18-4

1,1,2,2-tetrachloroethylene

B

chloroform
67-66-3

chloroform

C

N1,N1-diethyl-N2-phenylsulfonylformamidine
29665-24-5

N1,N1-diethyl-N2-phenylsulfonylformamidine

Conditions
ConditionsYield
In dichloromethane at 0℃; for 24h;A n/a
B n/a
C 98%
Schwartz's reagent

Schwartz's reagent

A

zirconocene dichloride
1291-32-3

zirconocene dichloride

B

chloroform
67-66-3

chloroform

Conditions
ConditionsYield
With tetrachloromethane In toluene under Ar; elem. anal.;A 98%
B 62%
Trichlormethansulfinsaeureanilid
42521-52-8

Trichlormethansulfinsaeureanilid

A

chloroform
67-66-3

chloroform

B

N-phenylsulfinylamine
222851-56-1

N-phenylsulfinylamine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Ambient temperature;A n/a
B 97.2%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

1-amino-2-propene
107-11-9

1-amino-2-propene

A

chloroform
67-66-3

chloroform

B

2,2,2-trichloro-N-(2-propenyl)acetamide
39089-56-0

2,2,2-trichloro-N-(2-propenyl)acetamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 97%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

ethanolamine
141-43-5

ethanolamine

A

chloroform
67-66-3

chloroform

B

2,2,2-trichloro-N-(2-hydroxyethyl)acetamide
35234-31-2

2,2,2-trichloro-N-(2-hydroxyethyl)acetamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 96%
tetrachloromethane
56-23-5

tetrachloromethane

di-n-propylmercury
628-85-3

di-n-propylmercury

A

mercury(I) chloride

mercury(I) chloride

B

1-Chloropropane
540-54-5

1-Chloropropane

C

chloroform
67-66-3

chloroform

D

n-propylmercury(II) chloride
2440-40-6

n-propylmercury(II) chloride

E

mercury

mercury

Conditions
ConditionsYield
In neat (no solvent) 150°C, 60 h; further products;A <1
B 96%
C >99
D 5%
E 95%
pentachloroacetone
1768-31-6

pentachloroacetone

ethanolamine
141-43-5

ethanolamine

A

chloroform
67-66-3

chloroform

B

2,2-dichloro-N-(2-hydroxyethyl)acetamide
6419-44-9

2,2-dichloro-N-(2-hydroxyethyl)acetamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 95.4%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

methylamine
74-89-5

methylamine

A

chloroform
67-66-3

chloroform

B

N-methyltrichloroacetamide
23170-77-6

N-methyltrichloroacetamide

Conditions
ConditionsYield
In hexane Heating;A n/a
B 95.2%
tetrachloromethane
56-23-5

tetrachloromethane

oxygen
80937-33-3

oxygen

diisopropylmercury
1071-39-2

diisopropylmercury

A

propane
74-98-6

propane

B

isopropyl chloride
75-29-6

isopropyl chloride

C

chloroform
67-66-3

chloroform

D

isopropylmercury(II) chloride
30615-19-1

isopropylmercury(II) chloride

E

mercury

mercury

Conditions
ConditionsYield
In neat (no solvent) 20°C, 96 h; further products;A 4%
B 48%
C 30%
D 95%
E 5%
pentachloroacetone
1768-31-6

pentachloroacetone

N-butylamine
109-73-9

N-butylamine

A

chloroform
67-66-3

chloroform

B

2,2-dichloro-N-butylacetamide
5345-74-4

2,2-dichloro-N-butylacetamide

Conditions
ConditionsYield
In hexaneA n/a
B 93.9%
1,1,1,3,3-pentachlorobutanone
64697-39-8

1,1,1,3,3-pentachlorobutanone

ethanolamine
141-43-5

ethanolamine

A

chloroform
67-66-3

chloroform

B

2,2-Dichloro-N-(2-hydroxy-ethyl)-propionamide
83704-00-1

2,2-Dichloro-N-(2-hydroxy-ethyl)-propionamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 93.5%
1,1,1,3,3-pentachlorobutanone
64697-39-8

1,1,1,3,3-pentachlorobutanone

1-amino-2-propene
107-11-9

1-amino-2-propene

A

chloroform
67-66-3

chloroform

B

N-Allyl-2,2-dichloro-propionamide
83703-99-5

N-Allyl-2,2-dichloro-propionamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 93.5%
1,1,1,3,3,3-hexachloro-propan-2-one
116-16-5

1,1,1,3,3,3-hexachloro-propan-2-one

ethanol
64-17-5

ethanol

2,2,3,3-tetrafluoropropanol
76-37-9

2,2,3,3-tetrafluoropropanol

A

chloroform
67-66-3

chloroform

B

2,2,3,3-Tetrafluor-propyl-propionat
2062-06-8

2,2,3,3-Tetrafluor-propyl-propionat

Conditions
ConditionsYield
Stage #1: 1,1,1,3,3,3-hexachloro-propan-2-one; ethanol With potassium fluoride at 30℃; for 1h; pressure tight reactor;
Stage #2: 2,2,3,3-tetrafluoropropanol at 100℃;
A 93%
B 74%
pentachloroacetone
1768-31-6

pentachloroacetone

1-pentanamine
110-58-7

1-pentanamine

A

chloroform
67-66-3

chloroform

B

N-Pentyl-2,2-dichloroacetamide
83703-97-3

N-Pentyl-2,2-dichloroacetamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 92%
1,1,1,3,3-pentachlorobutanone
64697-39-8

1,1,1,3,3-pentachlorobutanone

1-pentanamine
110-58-7

1-pentanamine

A

chloroform
67-66-3

chloroform

B

2,2-Dichloro-N-pentyl-propionamide
83703-98-4

2,2-Dichloro-N-pentyl-propionamide

Conditions
ConditionsYield
In hexane for 0.5h;A n/a
B 92%
N-(2,2,2-trichloroethylidene)benzenesulfonamide
55596-11-7

N-(2,2,2-trichloroethylidene)benzenesulfonamide

dimethyl amine
124-40-3

dimethyl amine

A

1,1,2,2-tetrachloroethylene
127-18-4

1,1,2,2-tetrachloroethylene

B

chloroform
67-66-3

chloroform

C

N,N-dimethyl-N′-(phenylsulfonyl)formimidamide
13707-43-2

N,N-dimethyl-N′-(phenylsulfonyl)formimidamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;A n/a
B n/a
C 92%
1-Decanol
112-30-1

1-Decanol

pentachloroacetone
1768-31-6

pentachloroacetone

A

chloroform
67-66-3

chloroform

B

decyl 2,2-dichloroacetate
83005-00-9

decyl 2,2-dichloroacetate

Conditions
ConditionsYield
With triethylamine Heating;A n/a
B 91.4%
tetrachloromethane
56-23-5

tetrachloromethane

diisopropylmercury
1071-39-2

diisopropylmercury

A

mercury(I) chloride

mercury(I) chloride

B

isopropyl chloride
75-29-6

isopropyl chloride

C

chloroform
67-66-3

chloroform

D

isopropylmercury(II) chloride
30615-19-1

isopropylmercury(II) chloride

E

mercury

mercury

Conditions
ConditionsYield
In neat (no solvent) 130°C, 10 h; further products;A 3%
B 51%
C 50%
D 91%
E 3%
styrene
292638-84-7

styrene

chloroform
67-66-3

chloroform

1,1-dichloro-2-phenylcyclopropane
2415-80-7

1,1-dichloro-2-phenylcyclopropane

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide; 1,3,5-trimethyl-benzene In dichloromethane at 40℃; for 6h;100%
With PEG-supported tetrakis ammonium salt In dichloromethane at 25℃; for 0.5h;98%
With tetrabutylammomium bromide; sodium hydroxide In dichloromethane at 20℃; for 0.0833333h;96%
chloroform
67-66-3

chloroform

cyclohexene
110-83-8

cyclohexene

7,7-dichloro-bicyclo[4.1.0]heptane
823-69-8

7,7-dichloro-bicyclo[4.1.0]heptane

Conditions
ConditionsYield
With sodium hydroxide; Sucrose-ethyleneoxide adducts In chloroform at 20℃; for 2h; Product distribution; further catalysts: PEG, DB18K6; further objects of study: phase-transfer catalysis;;100%
With sodium hydroxide; Sucrose-ethyleneoxide adducts In chloroform at 20℃; for 2h; Product distribution; further catalysts: PEG, DB18K6;100%
With potassium hydroxide; 18-crown-6 ether In dichloromethane at 40℃; for 6h;98%
styrene
292638-84-7

styrene

chloroform
67-66-3

chloroform

1,1,3-trichloro-3-phenylpropane
42956-39-8

1,1,3-trichloro-3-phenylpropane

Conditions
ConditionsYield
With Grubbs catalyst first generation at 65℃; for 2h;100%
Grubbs catalyst first generation at 65 - 80℃; Kharasch addition;99%
With N2[(RuCl2)2(1,3,5-iPr3C6H3)(tricyclohexylphosphine]2 In toluene at 40℃; for 48h;93%
chloroform
67-66-3

chloroform

Bis(2,4,6-tri-tert-butylphenyl)diphosphen
83466-54-0, 93602-74-5, 79073-99-7

Bis(2,4,6-tri-tert-butylphenyl)diphosphen

1,2-bis(2,4,6-tri-tert-butylphenyl)3,3-dichloro diphosphirane
111888-01-8, 126976-48-5

1,2-bis(2,4,6-tri-tert-butylphenyl)3,3-dichloro diphosphirane

Conditions
ConditionsYield
With potassium hydroxide In hexane at 15℃; for 2h; sonication;100%
With potassium tert-butylate
chloroform
67-66-3

chloroform

3,3-Diethyl-6,7-dimethoxy-1-phenyl-3,4-dihydro-isoquinoline
132067-80-2

3,3-Diethyl-6,7-dimethoxy-1-phenyl-3,4-dihydro-isoquinoline

6,7-Dimethoxy-8bphenyl-1,1-dichloro-3,3-diethyl-1,3,4,8b-tetrahydroazirino<2,1-a>isoquinoline
132067-87-9

6,7-Dimethoxy-8bphenyl-1,1-dichloro-3,3-diethyl-1,3,4,8b-tetrahydroazirino<2,1-a>isoquinoline

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In hexane 1) 3 h, 12 deg C 2) 1 h, 20 deg C;100%
chloroform
67-66-3

chloroform

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

Vilsmeier-Haack reagent

Vilsmeier-Haack reagent

Conditions
ConditionsYield
With trichlorophosphate at 20℃; for 0.5h;100%
chloroform
67-66-3

chloroform

4-Ethoxyaniline
156-43-4

4-Ethoxyaniline

acetone
67-64-1

acetone

α-p-phenetidino-isobutyric acid p-phenetidide
74262-33-2

α-p-phenetidino-isobutyric acid p-phenetidide

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 5℃;100%
chloroform
67-66-3

chloroform

(3aR,6aR)-4-Dichloromethylene-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

(3aR,6aR)-4-Dichloromethylene-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

(3'aR)-2,2,3,3-tetrachloro-2',2'-dimethyl-(3'ar,6'ac)-tetrahydrospiro(cyclopropane-1,4'-furo[3,4-d][1,3]dioxolane)

(3'aR)-2,2,3,3-tetrachloro-2',2'-dimethyl-(3'ar,6'ac)-tetrahydrospiro(cyclopropane-1,4'-furo[3,4-d][1,3]dioxolane)

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride 0 deg C, 30 min; RT, 2.5 h;100%
chloroform
67-66-3

chloroform

palmatine chloride
10605-02-4

palmatine chloride

8-trichloromethyl-7,8-dihydropalmatine
50932-23-5

8-trichloromethyl-7,8-dihydropalmatine

Conditions
ConditionsYield
With ammonium hydroxide for 24h;100%
With ammonium hydroxide at 20℃; for 24h;74.9%
chloroform
67-66-3

chloroform

(Z)-2,3-Diphenyl-acrylic acid 2-[(E)-phenyliminomethyl]-phenyl ester

(Z)-2,3-Diphenyl-acrylic acid 2-[(E)-phenyliminomethyl]-phenyl ester

2-(1,2-diphenylvinyl)-2,5-epoxy-4-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one

2-(1,2-diphenylvinyl)-2,5-epoxy-4-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one

Conditions
ConditionsYield
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 20℃;100%
C20H29NO3
618103-13-2

C20H29NO3

chloroform
67-66-3

chloroform

C21H29Cl2NO3
618103-14-3

C21H29Cl2NO3

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In water for 16h;100%
4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline

4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline

chloroform
67-66-3

chloroform

4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline

4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline

Conditions
ConditionsYield
palladium In methanol; N,N-dimethyl-formamide100%
palladium In methanol; N,N-dimethyl-formamide100%
4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline hydrochloride

4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline hydrochloride

chloroform
67-66-3

chloroform

4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride

4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride

Conditions
ConditionsYield
palladium In methanol; N,N-dimethyl-formamide100%
1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II)

1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II)

chloroform
67-66-3

chloroform

dicarbonylchloro(η5-1-hydroxy-2,3,4,5-tetraphenylcyclopentadienyl)ruthenium(II)

dicarbonylchloro(η5-1-hydroxy-2,3,4,5-tetraphenylcyclopentadienyl)ruthenium(II)

Conditions
ConditionsYield
In ethanol; chloroform byproducts: CH2Cl2, CH3CHO; (Ar); using Schlenk techniques; dissolving of ((Ph4C4CO)2H)Ru2(CO)4(H) in degassed CHCl3 and C2H5OH; closing of flask, stirring at 90°C for 7 h; removal of solvent under high vac., elem .anal.;100%
chloroform
67-66-3

chloroform

bis[tris-(3,5-dimethyl-2-oxidobenzyl-κO)ammonium]zirconium(IV)

bis[tris-(3,5-dimethyl-2-oxidobenzyl-κO)ammonium]zirconium(IV)

bis[tris-(3,5-dimethyl-2-oxidobenzyl-κO)ammonium]zirconium(IV) chloroform disolvate

bis[tris-(3,5-dimethyl-2-oxidobenzyl-κO)ammonium]zirconium(IV) chloroform disolvate

Conditions
ConditionsYield
In chloroform Zr((CH3)2C6H2(O)CH2)3NH) dissolved in dry CHCl3 in air; recrystd.; elem. anal.; detd. by XRD;100%
chloroform
67-66-3

chloroform

bis(η2-ethene)[η5-(8-quinolyl)cyclopentadienyl]iridium(I)
866488-88-2

bis(η2-ethene)[η5-(8-quinolyl)cyclopentadienyl]iridium(I)

[η5-(8-quinolyl)cyclopentadienyl]dichloridoiridium(III)
1184999-49-2

[η5-(8-quinolyl)cyclopentadienyl]dichloridoiridium(III)

Conditions
ConditionsYield
In chloroform Irradiation (UV/VIS); under Ar atm.soln. Ir complex in CHCl3 was irradiated for 3 days with light 150-W Hg high-pressure lamp; solvent was evapd.;100%
chloroform
67-66-3

chloroform

(OC-6-54-C) μ-chlorido, μ-hydroxo, bis(cis-dicarbonyl, [2,2'-phenylene-4,5-(R,R)-pinenopyridine-κC,N]ruthenium(II))

(OC-6-54-C) μ-chlorido, μ-hydroxo, bis(cis-dicarbonyl, [2,2'-phenylene-4,5-(R,R)-pinenopyridine-κC,N]ruthenium(II))

bis(cis-dicarbonyl, μ-chlorido, [2,2'-phenylene-4,5-(R,R)-pinenopyridine-κC,N]ruthenium(II))*CH2Cl2

bis(cis-dicarbonyl, μ-chlorido, [2,2'-phenylene-4,5-(R,R)-pinenopyridine-κC,N]ruthenium(II))*CH2Cl2

Conditions
ConditionsYield
In chloroform 80°C, 48 h;100%
1,4,7-trithiacyclononane
6573-11-1

1,4,7-trithiacyclononane

di-μ-chlorobis(azobenzene-2C,N)dipalladium(II)

di-μ-chlorobis(azobenzene-2C,N)dipalladium(II)

chloroform
67-66-3

chloroform

acetone
67-64-1

acetone

[Pd(C6H4N=NC6H5)(1,4,7-trithiacyclononane)][Pd(C6H4N=NC6H5)(Cl2)]*CHCl3

[Pd(C6H4N=NC6H5)(1,4,7-trithiacyclononane)][Pd(C6H4N=NC6H5)(Cl2)]*CHCl3

Conditions
ConditionsYield
In dichloromethane byproducts: AgCl; under N2 or Ar using Schlenk app.; CH2Cl2 added to solid mixt. of (Pd(C6H4NNC6H5)Cl)2 (0.20 mol) and 1,4,7-trithiacyclononane (0.40 mol); stirred for 18 h; filtered; evapd. to dryness; extd. (MeOH); ext. filtered and evapd. to dryness; crystd. (CHCl3 and hexane) at room temp. for 3 d;100%
(tetrahydrothiophene)gold(I) chloride
39929-21-0

(tetrahydrothiophene)gold(I) chloride

chloroform
67-66-3

chloroform

(C5H5O2(OCH3)2CH2OCH3)5(PC6H5(CH2C5H5O2(OCH3)2)2)

(C5H5O2(OCH3)2CH2OCH3)5(PC6H5(CH2C5H5O2(OCH3)2)2)

P-chlorido-[6(A),6(B)-dideoxy-6(A),6(B)-[(R)-phenylphosphinidene]-2(A),2(B),2(C),2(D),2(E),2(F),2(G),3(A),3(B),3(C),3(D),3(E),3(G),6(C),6(D),6(E),6(F),6(G)-nonadeca-O-methyl-β-cyclodextrin]gold(I)*0.5CHCl3

P-chlorido-[6(A),6(B)-dideoxy-6(A),6(B)-[(R)-phenylphosphinidene]-2(A),2(B),2(C),2(D),2(E),2(F),2(G),3(A),3(B),3(C),3(D),3(E),3(G),6(C),6(D),6(E),6(F),6(G)-nonadeca-O-methyl-β-cyclodextrin]gold(I)*0.5CHCl3

Conditions
ConditionsYield
In dichloromethane (Schlenk, N2) to stirred soln. of phosphane in CH2Cl2 was added to a soln. of Au-complex in CH2Cl2, 30 min; evapd. to dryness, column chromy. (silica gel, CH2Cl2-CH3OH, 96:4, v/v);elem. anal.;100%
chloroform
67-66-3

chloroform

2,4,6-trimethylaniline
88-05-1

2,4,6-trimethylaniline

2-mesityl isocyanide
57116-96-8

2-mesityl isocyanide

Conditions
ConditionsYield
Stage #1: 2,4,6-trimethylaniline With 15-crown-5; sodium hydride In benzene at 40 - 50℃; for 0.25h;
Stage #2: chloroform In benzene at 40℃; for 1h;
100%
With benzyltriethylammonium chloride; sodium hydroxide In dichloromethane; water for 22h;53%
chloroform
67-66-3

chloroform

C81H64N4O4

C81H64N4O4

C85H64Cl8N4O4

C85H64Cl8N4O4

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In chloroform; water at 40 - 45℃; for 1h;100%
chloroform
67-66-3

chloroform

C63H53N3O3

C63H53N3O3

C66H53Cl6N3O3

C66H53Cl6N3O3

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 40 - 45℃; for 1h;100%
chloroform
67-66-3

chloroform

C45H42N2O3

C45H42N2O3

C47H42Cl4N2O3

C47H42Cl4N2O3

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 40 - 45℃;100%

67-66-3Relevant articles and documents

Gas-phase photooxidation of trichloroethylene on TiO2 and ZnO: Influence of trichloroethylene pressure, oxygen pressure, and the photocatalyst surface on the product distribution

Driessen,Goodman,Miller,Zaharias,Grassian

, p. 549 - 556 (1998)

Transmission Fourier transform infrared spectroscopy has been used to identify gas-phase and surface-bound products and intermediates formed during the gas-phase photooxidation of trichloroethylene (TCE) on TiO2 and ZnO. Several factors are found to influence the gas-phase product distribution for this reaction. On clean TiO2 and ZnO surfaces and at high TCE and O2 pressures, gas-phase CO, CO2, COCl2, CCl2HCOCl, CHCl3, C2HCl5, and HCl are produced, whereas at low TCE and O2 pressures, TCE is converted to gas-phase CO and CO2 only. In addition to TCE and O2 pressure, the product distribution of the photooxidation of TCE is strongly dependent upon the coverage of adsorbed species on the surface of the photocatalyst. It is shown here that the complete oxidation of adsorbed TCE can occur on clean photocatalytic surfaces whereas only partial oxidation of adsorbed TCE occurs on adsorbate-covered surfaces. The role of adsorbed surface products in TCE photooxidation is discussed.

Kinetics of the R + HBr ? RH + Br (R = CH2Br, CHBrCl or CCl3) equilibrium. Thermochemistry of the CH2Br and CHBrCl radicals

Seetula, Jorma A.

, p. 849 - 855 (2003)

The kinetics of the reaction of the CH2Br, CHBrCl or CCl3 radicals, R, with HBr have been investigated separately in a heatable tubular reactor coupled to a photoionization mass spectrometer. The CH2Br (or CHBrCl or CCl3) radical was produced homogeneously in the reactor by a pulsed 248 nm exciplex laser photolysis of CH2Br2 (or CHBr2Cl or CBrCl3). The decay of R was monitored as a function of HBr concentration under pseudo-first-order conditions to determine the rate constants as a function of temperature. The reactions were studied separately over a wide ranges of temperatures and in these temperature ranges the rate constants determined were fitted to an Arrhenius expression (error limits stated are 1σ + Student's t values, units in cm3 molecule-1 s-1): k(CH2Br + HBr) = (7.5 ± 0.9) × 10-13 exp[- (2.53 ± 0.13) kJ mol-1/RT], k(CHBrCl + HBr) = (4.9 ± 1.1) × 10-13 exp[-(8.2 ± 0.3) kJ mol-1/RT] and k(CCl3 + HBr) -15 at 787 K. The kinetics of the reverse reactions, Br + R′H → HBr + R′ (R′ = CH2Br or CHBrCl), were taken from the literature and also calculated by ab initio methods at the MP2(fc)/6-31G(d,p)//MP2(fc)/6-31G(d,p) level of theory in conjunction with the thermodynamic transition state theory to calculate the entropy and the enthalpy of formation values of the radicals studied. The thermodynamic values were obtained at 298 K using a second-law method. The results for entropy values are as follows (units in J K-1 mol-1): 263 ± 7 (CH2Br) and 294 ± 6 (CHBrCl). The results for enthalpy of formation values at 298 K are (in kJ mol-1): 171.1 ± 2.7 (CH2Br) and 143 ± 6 (CHBrCl). The C-H bond strength of analogous halomethanes are (in kJ mol-1): 427.2 ± 2.4 (CH3Br) and 406.0 ± 2.4 (CH2BrCl). Thermodynamic properties of the CH2Br radical were calculated by statistical thermodynamic methods over the temperature range 100-1500 K.

KINETICS OF THE GAS-PHASE PHOTOCHLORINATION OF DICHLOROMETHANE IN A TUBULAR PHOTOREACTOR.

Sugawara,Suzuki,Ohashi

, p. 854 - 859 (1980)

The kinetics were studied with due consideration taken of the radial variation in light intensity across the reactor and with the proper selection of kinetic equations, including the recombination of dichloromethyl radicals as the dominant termination step. The dependence of the absorbed radiant energy on the chlorine concentration was well simulated by the use of the radial-light and line-source model. The predominance of the observed production rate of hydrogen chloride over that of chloroform was also reproduced well by the appropriately selected kinetic expressions, without any use of the long-chain approximation. This work is pertinent to photochemical reactor design.

Investigation of the behaviour of haloketones in water samples

Nikolaou, Anastasia D.,Lekkas, Themistokles D.,Kostopoulou, Maria N.,Golfinopoulos, Spyros K.

, p. 907 - 912 (2001)

The behaviour of the haloketones (HKs) 1,1-Dichloropropanone (1,1-DCP), 1,1,1-Trichloropropanone (1,1,1-TCP) and 1,3-Dichloropropanone (1,3-DCP) in ultrapure water solutions and in fortified drinking water samples was invest/gated. Their concentrations were determined at regular time intervals by the use of a gas chromatography-electron capture detector (GC-ECD) method. Two different temperatures were studied. The results have shown that HKs decompose both in ultrapure water solutions and in drinking water samples. The decomposition rates are higher in the drinking water samples, especially at higher temperature. 1,1,1-TCP is the compound which decomposes fastest followed by 1,3-DCP and 1,1-DCP. Chloroform was formed both in the ultrapure water solutions and in the drinking water samples, probably due to the decomposition of 1,1,1-TCP. In the drinking water samples, formation of chloral hydrate was also observed.

The formation and control of disinfection by-products using chlorine dioxide

Chang, Chen-Yu,Hsieh, Yung-Hsu,Shih, I-Chen,Hsu, Shen-Sheng,Wang, Kuo-Hua

, p. 1181 - 1186 (2000)

In this study, chlorine dioxide (ClO2) was used as an alternative disinfectant with vanillic acid, p-hydroxybenzoic acid, and humic acid as the organic precursors in a natural aquatic environment. The primary disinfection by-products (DBPs) formed were trihalomethanes (THMs) and haloacetic acids (HAAs). Under neutral conditions (pH = 7) for vanillic acid, more total haloacetic acids (THAAs) than total trihalomethanes (TTHMs) were found, with a substantial increase during the later stages of the reaction. In the case of p-hydroxybenzoic acid, the amount of THAAs produced was minimal. Raising the concentration of ClO2 was not favorable for the control of THAAs in low concentrations of vanillic acid. ClO2 could reduce the total amount of TTHMs and THAAs for higher concentration of vanillic acid. It was found that the humic acid treatment dosage was not significant. Under alkaline conditions (pH = 9), the control of TTHMs and THAAs for the treatment of vanillic acid was better and more economical, however, an appreciable amount of inorganic by-products were observed. Under the same alkaline condition, the control of THAA for the treatment of p-hydroxybenzoic acid was not beneficial and for the treatment of humic acid was not significant. (C) 2000 Elsevier Science Ltd.

Mechanistic studies of the photocatalytic oxidation of trichloroethylene with visible-light-driven N-doped TiO2 photocatalysts

Joung, Soon-Kil,Amemiya, Takashi,Murabayashi, Masayuki,Itoh, Kiminori

, p. 5526 - 5534 (2006)

Visible-light-driven TiO2 photocatalysts doped with nitrogen have been prepared as powders and thin films in a cylindrical tubular furnace under a stream of ammonia gas. The photocatalysts thus obtained were found to have a band-gap energy of 2.95 eV. Electron spin resonance (ESR) under irradiation with visible light (λ ≥ 430 nm) afforded the increase in intensity in the visible-light region. The concentration of trapped holes was about fourfold higher than that of trapped electrons. Nitrogendoped TiO 2 has been used to investigate mechanistically the photocatalytic oxidation of trichloroethylene (TCE) under irradiation with visible light (λ ≥ 420 nm). Cl and O radicals, which contribute significantly to the generation of dichloroacetyl chloride (DCAC) in the photocatalytic oxidation of TCE under UV irradiation, were found to be deactivated under irradiation with visible light. As the main by-product. only phosgene was detected in the photocatalytic oxidation of TCE under irradiation with visible light. Thus, the reaction mechanism of TCE photooxidation under irradiation with visible light clearly differs markedly from that under UV irradiation. Based on the results of the present study, we propose a new reaction mechanism and adsorbed species for the photocatalytic oxidation of TCE under irradiation with visible light. The energy band for TiO2 by doping with nitrogen may involve an isolated band above the valence band.

Isoflurane enhances dechlorination of carbon tetrachloride in guinea-pig liver microsomes

Fujii, Kohyu,Rahman, Md. Mustafizur,Yuge, Osafumi

, p. 249 - 253 (1996)

Effect of isoflurane on the dechlorination of carbon tetrachloride to chloroform was investigated in the guinea-pip liver microsomes. Under anaerobic conditions, chloroform is produced from carbon tetrachloride through the microsomes in the presence of NADPH, and such production of chloroform was increased by the addition of isoflurane. The K(m) for the production of chloroform from carbon tetrachloride was decreased to 86% by isoflurane compared with the control; however the maximum velocity of chloroform production was also decreased to 50%. The formation of the 445 nm band in the mixture of reduced cytochrome P-450 and carbon tetrachloride, and cytochrome P-450 reduction by NADPH were both accelerated by isoflurane, without alteration of NADPH-cytochrome c reductase activity. These results indicate that trichloromethyl radical, an intermediate product of carbon tetrachloride, easily combines to the haeme part of cytochrome P-450, whereas the protein part combines to isoflurane after being reduced by NADPH, which results in acceleration of carbon tetrachloride dechlorination under a lower concentration of carbon tetrachloride. These results may have implications for other drugs that are administered during isoflurane anaesthesia.

Electrochemical investigation of the rate-limiting mechanisms for trichlomethylene and carbon tetrachloride reduction at iron surfaces

Li, Tie,Farrell, James

, p. 3560 - 3565 (2001)

The mechanisms involved in reductive dechlorination of carbon tetrachloride (CT) and trichloroethylene (TCE) at iron surfaces were studied to determine if their reaction rates were limited by rates of electron transfer. Chronoamperometry and chronopotentiometry analyses were used to determine the kinetics of CT and TCE reduction by a rotating disk electrode in solutions of constant halocarbon concentration. Rate constants for CT and TCE dechlorination were measured as a function of the electrode potential over a temperature range from 2 to 42 °C. Changes in dechlorination rate constants with electrode potential were used to determine the apparent electron-transfer coefficients at each temperature. The transfer coefficient for CT dechlorination was 0.22 ± 0.02 and was independent of temperature. The temperature independence of the CT transfer coefficient is consistent with a rate-limiting mechanism involving an outer-sphere electron-transfer step. Conversely, the transfer coefficient for TCE was temperature dependent and ranged from 0.06 ± 0.01 at 2 °C to 0.21 ± 0.02 at 42 °C. The temperature-dependent TCE transfer coefficient indicated that its reduction rate was limited by chemical dependent factors and not exclusively by the rate of electron transfer. In accord with a rate-limiting mechanism involving an electron-transfer step, the apparent activation energy (Ea) for CT reduction decreased with decreasing electrode potential and ranged from 33.0 ± 1.6 to 47.8 ± 2.0 kJ/mol. In contrast, the E, for TCE reduction did not decline with decreasing electrode potential and ranged from 29.4 ± 3.4 to 40.3 ± 3.9. The absence of a potential dependence for the TCE Ea supports the conclusion that its reaction rate was not limited by an electron-transfer step. The small potential dependence of TCE reaction rates can be explained by a reaction mechanism in which TCE reacts with atomic hydrogen produced from reduction of water.

Formation of chloroform by aqueous chlorination of organic compounds

Chaidou,Georgakilas,Stalikas,Saraci,Lahaniatis

, p. 587 - 594 (1999)

Thirty organic compounds were selected to investigate their chloroform formation characteristics during chlorination with sodium hypochlorite at pH-values 7.0 and 8.0. These experiments were conducted under conditions similar to those applied on the chlorination of raw water. The results indicated that the chloroform concentrations occurred by the all tested compounds was in the ppm range. The maximum levels of chloroform (11-13 mg/l) were determined during the reaction of resorcinol and phloroglucinol at pH-value 8.0.

Stimulatory effect of anesthetics on dechlorination of carbon tetrachloride in guinea-pig liver microsomes

Fujii, Kohyu

, p. 147 - 153 (1996)

Effects of the anesthetics isoflurane, enflurane, halothane and sevoflurane on the dechlorination of carbon tetrachloride to produce chloroform were investigated using guinea pig liver microsomes. Under anaerobic conditions, chloroform is produced from carbon tetrachloride by the microsomes in the presence of NADPH, and chloroform production from 86 μM carbon tetrachloride was enhanced to 146%, 133%, 123% and 115% by the addition of isoflurane, enflurane, halothane and sevoflurane, respectively. The half-life of oxidized cytochrome P450 which remained during the reduction by the addition of NADPH was shortened to 51%, 54%, 60% and 80% by isoflurane, enflurane, halothane and sevoflurane, respectively, without alteration of NADPH-cytochrome c reductase activity. These anesthetics hastened the onset of the 445 nm absorption band formation which was shown by microsomes with carbon tetrachloride in the presence of NADPH under anaerobic conditions. These results indicate that the anesthetics isoflurane, enflurane, sevoflurane and halothane stimulate the reduction of cytochrome P450 results in the acceleration of the carbon tetrachloride dechlorination. These results may have implications for other type II drugs that are administered during anesthesia.