20776-52-7

Basic information

• Product Name: 2-amino-6-iodobenzoic acid
• Synonyms: 6-Iodoanthranilic acid;2-amino-6-iodobenzoic acid
• CAS NO: 20776-52-7
• Molecular Formula: C₇H₆INO₂
• Molecular Weight: 263.03
• Mol File: 20776-52-7.mol

Chemical Properties

• Melting Point: 162℃
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-amino-6-iodobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-iodobenzoic acid(20776-52-7)
• EPA Substance Registry System: 2-amino-6-iodobenzoic acid(20776-52-7)

Safety Data

• Hazardous Substances Data: 20776-52-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-amino-6-iodobenzoic acid is used as a building block in the synthesis of other chemical compounds due to its functional groups, which allow for various chemical reactions.
Used in Medicinal Chemistry:
Although not widely documented, 2-amino-6-iodobenzoic acid is used as a potential candidate in medicinal chemistry for its diverse biological activities, which may contribute to the development of new pharmaceuticals.
Used in Research and Development:
2-amino-6-iodobenzoic acid is utilized in research and development for studying its properties and exploring its potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI:1S/C7H6INO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,9H2,(H,10,11)

Upstream product

• 20780-75-0 4-iodo-1H-indole-2,3-dione 
• 5471-78-3 2-iodo-6-nitrobenzoic acid methylester 
• 118-92-3 anthranilic acid 
• 89641-04-3 2-iodo-6-nitrobenzoic acid 

Downstream Products

• 147494-20-0 methyl 2-amino-6-iodobenzoate 

Relevant articles and documents

Chemometric analysis of substituent effects. XI. Solvent effects on dissociation of 2,6-disubstituted benzoic acids

Eleven symmetrically 2,6-disubstituted benzoic acids (with the following substituents: OCH3, OC2H5, OC3H7, OCH(CH3)2, OC4H9, CH3, F, Cl, Br, I, a

A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations

Arylhalides are important building blocks in many fine chemicals, pharmaceuticals and agrochemicals, and there has been increasing interest in the development of more "green" halogenation methods based on enzyme catalysis. However, the screening and development of new enzymes for biohalogenation has been hampered by a lack of high-throughput screening methods. Described herein is the development of a colorimetric assay for detecting both chemical and enzymatic arylamine halogenation reactions in an aqueous environment. The assay is based on the unique UV/Vis spectrum created by the formation of an ortho-benzoquinone-amine adduct, which is produced by the peroxidase-catalysed benzoquinone generation, followed by Michael addition of either a halogenated or non-halogenated arylamine. This assay is sensitive, rapid and amenable to high-throughput screening platforms. We have also shown this assay to be easily coupled to a flavin-dependent halogenase, which currently lacks any convenient colorimetric assay, in a "one-pot" workflow.

Nickel Boride Reduction of Aryl Nitro Compounds

Nickel boride smoothly reduces aryl nitro compounds to the corresponding anilines in the presence of iodo and ortho carboalkoxy groups in contrast to the problematic reductions by other methods.