- A Chemoselective N-Arylation Reaction of 2-Aminopyridine Derivatives with Arynes
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A chemoselective N-arylation reaction of 2-aminopyridine derivatives with arynes in good to excellent yields has been described. The N-arylation products could be further applied to the facile construction of benzoisoquinuclidines and isoquinuclidines as
- Cheng, Bin,Wei, Jian,Zu, Bing,Zhao, Jianfei,Wang, Taimin,Duan, Xiaoguang,Wang, Renqi,Li, Yun,Zhai, Hongbin
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- N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants
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Compounds of formula [I] in which: W may represent a —(CH2)2—, —(CH2)3—, —CH2—C≡C— or —CH2—CH═CH— group, R2 may in particular represent a piperidyl group, an optionally substituted 1,2,3,6-tetrahydropyridyl group, a hexahydro-1H-azepinyl group, an optionally substituted piperazinyl group or a morpholinyl group, R3 may in particular represent a group —COR1, A may in particular represent an optionally substituted phenyl group, a heterocycle or a cyclopentyl group, and B may in particular represent a pyridyl group, an aminopyrazinyl group, an aminopyridazinyl group, a pyrimidinyl group optionally substituted with an amino group, piperidyl group or an aminopyridyl group optionally substituted on the pyridine with a (C1-C4)alkyl or (C1-C4)alkoxy group, the amino group possibly also being substituted with a (C1-C4)alkyl group, their preparation and their therapeutic application.
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- Synthesis of Functionalized 3-Pyridyl Methyl Ketones
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A synthesis of 3-pyridyl methyl ketones is described that employs a palladium-catalyzed olefination of 3-bromopyridines with butyl vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether in situ. This method has been applied to bromoquinoline substrates as well. The reaction is compatible with a variety of functional groups.
- Wright,Hageman,McClure
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p. 717 - 723
(2007/10/03)
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- Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
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The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain β-adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of t
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