- Highly Efficient Synthesis of Digoxin
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Taking advantage of the reliable stereocontrol capability of DMNPA group via long-distance-participation (LDP) effect as well as the mild and efficient deprotection conditions, the first and highly efficient synthesis of digoxin was achieved through a nine-step longest linear sequence with 41% overall yield.
- Liu, Hui,Zhou, Si-Yu,Liao, Jin-Xi,Tu, Yuan-Hong,Sun, Jian-Song
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- Enzymatic transformation of de-O-acetyl-lanatoside C into digoxin
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Keywords: De-O-acetyl-lanatoside C; Digoxin; Cyclodextrin; Enzymatic transformation; β-D-Glucosidase
- Lepojevic, Zika,Pekic, Branislav
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- Fluorescent dyes free of aggregation and serum binding
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Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.
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- 17-Phenyl-substituted steroidal compounds active on the cardiovascular system
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Cardioactive steroidal compounds of the formula I wherein, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings shown in the description, and pharmaceutical compositions containing them.
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- 7β-HYDROXYCARDENOLIDE GLYCOSIDES
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The microbial transformation of digitoxin (I) by Streptomyces sp. yielded digoxin (III) as main product along with the by-products 7β-hydroxydigitoxin (II) and 7β-hydroxydigoxin (IV).The present paper is concerned with the structure elucidation of 7β-hydroxycardenolides as well as with the formation of some of their derivatives.
- Szeleczky, Z.,Soti, M.,Horvath, Gy.,Albrecht, K.
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- Column chromatography specific binding assay method and test kit
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A specific binding assay method and test kit for determining a ligand, such as an antigen or antibody, in, or the ligand binding capacity of, a liquid medium, particularly a body fluid such as serum, wherein the unknown ligand competes with a labeled component, such as a radio labeled form of the ligand or of a binding analog of the ligand, for binding with a binding partner, with the improvement that separation of the resulting bound-species and free-species of the labeled component is accomplished by drawing the liquid reaction mixture into a column of an adsorbent material selective for one of the two species. Separation results by immobilization of the selected species at the beginning portion of the adsorbent column while the other species is transported farther along the column by advance of the reaction mixture. The present method is manipulatively simple and advantageous over the many known techniques; finds special application to radioimmunoassay, particularly for detecting low molecular weight ligands; and is readily adaptable to automation.
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- Pharmaceutical compositions containing a carboxylic acyl derivative of digoxin and method of use
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Pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula SPC1 Wherein R1 is alkyl of 2 to 12 carbon atoms, halo-(alkyl of 1 to 4 carbon atoms), aryl-(alkyl of 1 to 4 carbon atoms), cycloalkyl-(alkyl of 1 to 4 carbon atoms) or cycloalkyl of 3 to 8 carbon atoms; and a method of using the same as cardiotonics.
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