- Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ bindi
- Jennings, Lee D.,Foreman, Ken W.,Rush III, Thomas S.,Tsao, Desiree H. H.,Mosyak, Lidia,Li, Yuanhong,Sukhdeo, Mohani N.,Ding, Weidong,Dushin, Elizabeth G.,Kenny, Cynthia Hess,Moghazeh, Soraya L.,Petersen, Peter J.,Ruzin, Alexey V.,Tuckman, Margareta,Sutherland, Alan G.
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- Synthesis of 6-Oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine
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An efficient synthesis of 6-oxo-1,2,3,4,5,7,12,12b-octahydroindolo[2,3-α]quinolizine from 2-acetylpyridine and phenylhydrazine is described. This derivative of the natural alkaloid desbromoarborescidine A is an important entry point to the sarpagine-vobas
- Tompkins, David C.,Reilly, Laurence W.,Nelson, Randall B.,Dolby, Lloyd J.,Gribble, Gordon W.
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- Synthesis of 7-Oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine
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A short synthesis of 7-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine from 2-acetylpyridine and phenylhydrazine is described. Ring C is forged using 2-chloro-N,N-dimethylacetamide. This derivative of the natural alkaloid 1,2,3,4,6,7,12,12b-octah
- Tompkins, David C.,Nelson, Randall B.,Dolby, Lloyd J.,Gribble, Gordon W.
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- Amide derivative, preparation method of amide derivative, and application of amide derivative to pharmacy
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The invention provides an amide derivative, a preparation method of the amide derivative, and application of the amide derivative to pharmacy. The amide derivative compound is selected from one of the following structures. The compound can be used for preparing medicines in the fields of local anaesthesia or analgesia. (The formulas are as shown in the description).
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- Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist
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The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
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- BENZYL PIPERIDINE COMPOUNDS AS LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR ANTAGONIST
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The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
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