- Synthesis of 7-Oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine
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A short synthesis of 7-oxo-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine from 2-acetylpyridine and phenylhydrazine is described. Ring C is forged using 2-chloro-N,N-dimethylacetamide. This derivative of the natural alkaloid 1,2,3,4,6,7,12,12b-octah
- Tompkins, David C.,Nelson, Randall B.,Dolby, Lloyd J.,Gribble, Gordon W.
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p. 2168 - 2171
(2018/08/03)
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- Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ bindi
- Jennings, Lee D.,Foreman, Ken W.,Rush III, Thomas S.,Tsao, Desiree H. H.,Mosyak, Lidia,Li, Yuanhong,Sukhdeo, Mohani N.,Ding, Weidong,Dushin, Elizabeth G.,Kenny, Cynthia Hess,Moghazeh, Soraya L.,Petersen, Peter J.,Ruzin, Alexey V.,Tuckman, Margareta,Sutherland, Alan G.
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p. 1427 - 1431
(2007/10/03)
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