Design and synthesis of potent, selective inhibitors of endothelin- converting enzyme
Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion of its precursor by endothelin-converting enzyme-1 (ECE-1), a metalloprotease which displays high
Wallace, Eli M.,Moliterni, John A.,Moskal, Michael A.,Neubert, Alan D.,Marcopulos, Nicholas,Stamford, Lisa B.,Trapani, Angelo J.,Savage, Paula,Chou, Mary,Jeng, Arco Y.
p. 1513 - 1523
(2007/10/03)
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