209128-15-4

Basic information

• Product Name: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER
• Synonyms: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER;1-(Tert-Butoxycarbonyl)Spiro[Indene-1,4-Piperidine]-3-Carboxylic Acid(WX105032)
• CAS NO: 209128-15-4
• Molecular Formula: C₁₉H₂₃NO₄
• Molecular Weight: 329.39
• Mol File: 209128-15-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER(209128-15-4)
• EPA Substance Registry System: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER(209128-15-4)

Safety Data

• Hazardous Substances Data: 209128-15-4(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER is used as a building block for the synthesis of new drug candidates. Its unique structure and potential pharmacological properties make it a valuable component in the development of novel therapies for a range of medical conditions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER is utilized for its potential to contribute to the discovery of new medications. Its incorporation into drug molecules could enhance their efficacy, selectivity, and safety profiles, leading to improved treatments for various diseases.
Further research and testing are essential to fully explore the compound's potential applications and mechanisms of action, ensuring its safe and effective use in medical and pharmaceutical settings.

Upstream product

• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 
• 95-13-6 1-indene 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 185526-28-7 tert-butyl 3-bromospiro[indene-1,4'-piperidine]-1'-carboxylate 

Relevant articles and documents

Whole cell screen based identification of spiropiperidines with potent antitubercular properties

Abstract Whole cell based screens to identify hits against Mycobacterium tuberculosis (Mtb), carried out under replicating and non-replicating (NRP) conditions, resulted in the identification of multiple, novel but structurally related spiropiperidines with potent antitubercular properties. These compounds could be further classified into three classes namely 3-(3-aryl-1,2,4-oxadiazol-5-yl)-1′-alkylspiro[indene-1,4′-piperidine] (abbr. spiroindenes), 4-(3-aryl-1,2,4-oxadiazol-5-yl)-1′-alkylspiro[chromene-2,4′-piperidine] (abbr. spirochromenes) and 1′-benzylspiro[indole-1,4′-piperidin]-2(1H)-one (abbr. spiroindolones). Spiroindenes showed ≥4 log10 kill (at 2-12 μM) on replicating Mtb, but were moderately active under non replicating conditions. Whole genome sequencing efforts of spiroindene resistant mutants resulted in the identification of I292L mutation in MmpL3 (Mycobacterial membrane protein Large), required for the assembly of mycolic acid into the cell wall core of Mtb. MIC modulation studies demonstrated that the mutants were cross-resistant to spirochromenes but not to spiroindolones. This Letter describes lead identification efforts to improve potency while reducing the lipophilicity and hERG liabilities of spiroindenes. Additionally, as deduced from the SAR studies, we provide insights regarding the new chemical opportunities that the spiroindolones can offer to the TB drug discovery initiatives.

MODULATORS OF MUSCARINIC RECEPTORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.