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SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER is a spirocyclic chemical compound that features an indene and piperidine ring system. It is a derivative of spiro[1H-indene-1,4'-piperidine]-1',3-dicarboxylic acid, characterized by the presence of a 1,1-dimethyl ethyl ester group. SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER holds promise in medicinal chemistry due to its core structure found in various biologically active molecules.

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  • 1'-(TERT-BUTOXYCARBONYL)SPIRO[INDENE-1,4'-PIPERIDINE]-3-CARBOXYLIC ACID

    Cas No: 209128-15-4

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  • SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER

    Cas No: 209128-15-4

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  • 209128-15-4 Structure
  • Basic information

    1. Product Name: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER
    2. Synonyms: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER;1-(Tert-Butoxycarbonyl)Spiro[Indene-1,4-Piperidine]-3-Carboxylic Acid(WX105032)
    3. CAS NO:209128-15-4
    4. Molecular Formula: C19H23NO4
    5. Molecular Weight: 329.39
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 209128-15-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER(209128-15-4)
    11. EPA Substance Registry System: SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER(209128-15-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 209128-15-4(Hazardous Substances Data)

209128-15-4 Usage

Uses

Used in Medicinal Chemistry:
SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER is used as a building block for the synthesis of new drug candidates. Its unique structure and potential pharmacological properties make it a valuable component in the development of novel therapies for a range of medical conditions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER is utilized for its potential to contribute to the discovery of new medications. Its incorporation into drug molecules could enhance their efficacy, selectivity, and safety profiles, leading to improved treatments for various diseases.
Further research and testing are essential to fully explore the compound's potential applications and mechanisms of action, ensuring its safe and effective use in medical and pharmaceutical settings.

Check Digit Verification of cas no

The CAS Registry Mumber 209128-15-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,1,2 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 209128-15:
(8*2)+(7*0)+(6*9)+(5*1)+(4*2)+(3*8)+(2*1)+(1*5)=114
114 % 10 = 4
So 209128-15-4 is a valid CAS Registry Number.

209128-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1'-[(2-methylpropan-2-yl)oxycarbonyl]spiro[indene-3,4'-piperidine]-1-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:209128-15-4 SDS

209128-15-4Downstream Products

209128-15-4Relevant articles and documents

Whole cell screen based identification of spiropiperidines with potent antitubercular properties

Tantry, Subramanyam J.,Degiacomi, Giulia,Sharma, Sreevalli,Jena, Lalit Kumar,Narayan, Ashwini,Guptha, Supreeth,Shanbhag, Gajanan,Menasinakai, Sreenivasaiah,Mallya, Meenakshi,Awasthy, Disha,Balakrishnan, Gayathri,Kaur, Parvinder,Bhattacharjee, Deepa,Narayan, Chandan,Reddy, Jitendar,Naveen Kumar,Shandil, Radha,Boldrin, Francesca,Ventura, Marcello,Manganelli, Riccardo,Hartkoorn, Ruben C.,Cole, Stewart T.,Panda, Manoranjan,Markad, Shankar D.,Ramachandran, Vasanthi,Ghorpade, Sandeep R.,Dinesh, Neela

, p. 3234 - 3245 (2015/07/08)

Abstract Whole cell based screens to identify hits against Mycobacterium tuberculosis (Mtb), carried out under replicating and non-replicating (NRP) conditions, resulted in the identification of multiple, novel but structurally related spiropiperidines with potent antitubercular properties. These compounds could be further classified into three classes namely 3-(3-aryl-1,2,4-oxadiazol-5-yl)-1′-alkylspiro[indene-1,4′-piperidine] (abbr. spiroindenes), 4-(3-aryl-1,2,4-oxadiazol-5-yl)-1′-alkylspiro[chromene-2,4′-piperidine] (abbr. spirochromenes) and 1′-benzylspiro[indole-1,4′-piperidin]-2(1H)-one (abbr. spiroindolones). Spiroindenes showed ≥4 log10 kill (at 2-12 μM) on replicating Mtb, but were moderately active under non replicating conditions. Whole genome sequencing efforts of spiroindene resistant mutants resulted in the identification of I292L mutation in MmpL3 (Mycobacterial membrane protein Large), required for the assembly of mycolic acid into the cell wall core of Mtb. MIC modulation studies demonstrated that the mutants were cross-resistant to spirochromenes but not to spiroindolones. This Letter describes lead identification efforts to improve potency while reducing the lipophilicity and hERG liabilities of spiroindenes. Additionally, as deduced from the SAR studies, we provide insights regarding the new chemical opportunities that the spiroindolones can offer to the TB drug discovery initiatives.

MODULATORS OF MUSCARINIC RECEPTORS

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Page/Page column 41-43, (2008/06/13)

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

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