Technology Process of SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER
There total 7 articles about SPIRO[1H-INDENE-1,4'-PIPERIDINE]-1',3-DICARBOXYLIC ACID, 1,1-DIMETHYL ETHYL ESTER which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 3-bromospiro[indene-1,4'-piperidine]-1'-carboxylate;
With
water; sodium hydroxide;
In
methanol;
at 60 ℃;
for 2h;
With
hydrogenchloride;
In
water;
pH=5;
DOI:10.1016/j.bmcl.2015.05.087
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / dichloromethane / 6 h / 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere
2.2: 10 - 20 °C / Inert atmosphere
3.1: bromine / tetrahydrofuran / 2 h / 5 °C
4.1: potassium hydroxide / ethanol / 5 h / Reflux
5.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / 12 h / 110 °C / 5171.62 Torr
6.1: sodium hydroxide; water / methanol / 2 h / 60 °C
6.2: pH 5
With
1,3-bis-(diphenylphosphino)propane; water; bromine; palladium diacetate; triethylamine; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2015.05.087
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere
1.2: 10 - 20 °C / Inert atmosphere
2.1: bromine / tetrahydrofuran / 2 h / 5 °C
3.1: potassium hydroxide / ethanol / 5 h / Reflux
4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / 12 h / 110 °C / 5171.62 Torr
5.1: sodium hydroxide; water / methanol / 2 h / 60 °C
5.2: pH 5
With
1,3-bis-(diphenylphosphino)propane; water; bromine; palladium diacetate; triethylamine; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmcl.2015.05.087
