209260-76-4Relevant articles and documents
Condensed tricyclic compound and applications thereof in medicines
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Paragraph 0426-0431, (2020/04/17)
The invention relates to a condensed tricyclic compound and applications thereof in medicines, particularly to applications of the condensed tricyclic compound as a drug for treating and/or preventinghepatitis B, specifically to a compound represented by a general formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrugthereof, wherein variables are defined in the specification. The invention further relates to applications of the compound represented by the general formula (I) or the stereoisomer, the tautomer, thenitric oxide, the solvate, the metabolite, the pharmaceutically acceptable salt or the prodrug thereof as a drug, particularly applications of the compound as a drug for treating and/or preventing hepatitis B.
Epothilone analogs
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, (2008/06/13)
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.