4-Bromo-N,N-dimethyl-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-Bromo-N,N-dimethyl-1,3-thiazol-2-amine
• CAS No.: 209260-76-4
• Molecular Formula: C₅H₇BrN₂S
• Molecular Weight: 207.094
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10596040
• Wikidata: Q82491168
• Mol file: 209260-76-4.mol

Synonyms:209260-76-4;2-DIMETHYLAMINO-4-BROMOTHIAZOLE;4-BROMO-N,N-DIMETHYL-1,3-THIAZOL-2-AMINE;4-BROMO-N,N-DIMETHYLTHIAZOL-2-AMINE;2-Thiazolamine, 4-bromo-N,N-dimethyl-;MFCD09878986;4-BROMO-2-(DIMETHYLAMINO)THIAZOLE;SCHEMBL5637600;DTXSID10596040;JQIGVPZFJHWNID-UHFFFAOYSA-N;AMY17496;4-Bromo-N,N-dimethyl-2-thiazolamine;AKOS015945313;AB54152;BS-22047;SY288180;DB-212674;CS-0194461;E90302;EN300-1246551;A857127

Chemical Property of 4-Bromo-N,N-dimethyl-1,3-thiazol-2-amine

Chemical Property:

• PSA: 44.37000
• LogP: 1.97160
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 205.95133
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-N,N-dimethyl-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=NC(=CS1)Br

Technology Process of 4-Bromo-N,N-dimethyl-1,3-thiazol-2-amine

There total 2 articles about 4-Bromo-N,N-dimethyl-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 4-bromo-N,N-dimethylthiazol-2-amine (209260-76-4) + 2-Dimethylamino-4-tremthylstannylthiazole

Guidance literature:

Reference yield: 73.0%

N,N-dimethylammonium chloride (506-59-2) + 2,4-dibromo-1,3-thiazole (4175-77-3) → 4-bromo-N,N-dimethylthiazol-2-amine (209260-76-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 0 ℃;

Reference yield:

4-bromo-N,N-dimethylthiazol-2-amine (209260-76-4) → 10-acetyl-9-[2-(dimethylamino)-1,3-thiazol-4-yl]-2-oxo-6-(isopropyl)-2H,6H,7H-pyrido[2,1-a]isoquinoline-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether / 0.83 h / -78 °C

1.2: 20 °C

1.3: 0.17 h

2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; In 1,4-dioxane; diethyl ether;

upstream raw materials:

N,N-dimethylammonium chloride

2,4-dibromo-1,3-thiazole