Design and synthesis of new potent, silent 5-HT(1A) antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors
Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drags like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT(1A) antagonists (K(B) 1 nM for 7c and 9a).