Design and synthesis of new potent, silent 5-HT(1A) antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors

DOI: 10.1016/S0960-894X(98)00619-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3423 - 3428 (1998)

Update date:2022-08-03

Topics:

Authors:

Perez Perez

Pauwels Pauwels

Pallard-Sigogneau

Fourrier

Chopin Chopin

Palmier Palmier

Colovray

Halazy Halazy

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Article abstract of DOI:10.1016/S0960-894X(98)00619-2

Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drags like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT(1A) antagonists (K(B) < 1 nM for 7c and 9a).

Full text of DOI:10.1016/S0960-894X(98)00619-2

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