Design and synthesis of new potent, silent 5-HT(1A) antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors

Article abstract of DOI:10.1016/S0960-894X(98)00619-2

Hybrid molecules built up by covalent coupling of aminopropanol derivatives (especially pindolol) with antidepressant drags like fluoxetine, paroxetine or milnacipran were found to be potent and silent 5-HT(1A) antagonists (K(B) < 1 nM for 7c and 9a).