An efficient synthesis of 3-cyanoquinoline derivatives
A short and efficient method is reported for the preparation of 3- cyanoquinoline derivatives Reaction of 3,3-dimethoxy 2-formyl-propanenitrile sodium salt 1 with various anilines 2 afforded (E) enamines 3 which were subsequently isomerized into (Z) enamines 4 and cyclized in a one pot procedure to give 3-cyanoquinolines 5 in good yields.
Charpentier, Patricia,Lobregat, Virginie,Levacher, Vincent,Dupas, Georges,Queguiner, Guy,Bourguignon, Jean