Tetrahedron Letters p. 4013 - 4016 (1998)
Update date:2022-09-26
Topics:
Charpentier, Patricia
Lobregat, Virginie
Levacher, Vincent
Dupas, Georges
Queguiner, Guy
Bourguignon, Jean
A short and efficient method is reported for the preparation of 3- cyanoquinoline derivatives Reaction of 3,3-dimethoxy 2-formyl-propanenitrile sodium salt 1 with various anilines 2 afforded (E) enamines 3 which were subsequently isomerized into (Z) enamines 4 and cyclized in a one pot procedure to give 3-cyanoquinolines 5 in good yields.
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(1998)
