- Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis
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Transthyretin (TTR) is a ?-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. TTR also interacts with amyloid-β, playing a protective role in Alzheimer's disease. Dissociation of the nat
- Ciccone, Lidia,Nencetti, Susanna,Nicolo, Tonali,Carole, Fruchart-Gaillard,William, Shepard,Elisa, Nuti,Caterina, Camodeca,Armando, Rossello,Orlandini, Elisabetta
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- A mild system for synthesis of aldoximes and ketoximes in the presence of N-hydroxyphthalimide in aqueous system
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An efficient method for synthesis of oximes from aldehydes or ketones with N-hydroxyphthalimide or N-hydroxysuccinimide in water has been described. It is the first time to utilize NHPI as an oximation reagent to synthesize aldoximes and ketoximes from the corresponding organic carbonyl compounds without other reagents. The reaction tolerates various functional groups and affords the corresponding oximes in 76%–98% yields. The by-product phthalic acid can be recycled from the system. In addition, this method has been successfully applied to the synthesis of the precursor of some pharmacologically active amide molecules.
- Jiang, Xiaoying,Xu, Xiaohe,Lin, Yuyan,Yan, Yiyan,Li, Pingping,Bai, Renren,Xie, Yuanyuan
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supporting information
p. 5879 - 5885
(2018/09/06)
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- Chromatography-free entry to substituted salicylonitriles: Mitsunobu-triggered domino reactions of salicylaldoximes
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A mild and efficient one-pot procedure is described to transform salicylaldoximes into salicylonitriles using Mitsunobu chemistry. The reactions proceed through the corresponding 1,2-benzisoxazoles that undergo the Kemp elimination in situ to generate the
- Whiting, Ellis,Lanning, Maryanna E.,Scheenstra, Jacob A.,Fletcher, Steven
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p. 1229 - 1234
(2015/01/30)
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- 3-methyl-4-oxa-5-azahomoadamantane as an organocatalyst for the aerobic oxidation of primary amines to oximes in water
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A simple and efficient catalytic system for the aerobic oxidation of primary amines into corresponding oximes has been developed, with 3-methyl-4-oxa-5-azahomoadamantane as catalyst, acetaldoxime as co-catalyst and water as solvent. This process, which uses oxygen (O2) as an economic and green oxidant and water as a green solvent, tolerates a wide range of substrates, affording the target oximes in moderate to excellent yields. It was found that high selectivity was achieved when 3-methyl-4-oxa-5-azahomoadamantane was used, and E-type oximes were the only detected products. A possible mechanism for this catalytic process is proposed.
- Yu, Jiatao,Jin, Yong,Lu, Ming
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supporting information
p. 1175 - 1180
(2015/04/22)
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- A novel and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to oximes
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A simple and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to corresponding oximes by using toluene as the solvent is described. This practical method can use O2 as the economic and green oxidant, tolerate a wide range of substrates, which can afford the target oximes in moderate to excellent yields.
- Yu, Jiatao,Cao, Xiaohua,Lu, Ming
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supporting information
p. 5751 - 5755
(2015/02/02)
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- ALKYL-SUBSTITUTED 3' COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, Ar, m and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 29-30
(2010/02/17)
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- CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 91
(2010/04/03)
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- ACYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, Q, G, Ar, m, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 60
(2010/03/02)
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- PYRROLIDINE-SUBSTITUTED AZAINDOLE COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, A, B, D, E, G, Ar, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 40
(2010/02/17)
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- Simple, efficient and green synthesis of oximes under ultrasound irradiation
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The condensation of aldehydes andketones with hydroxylamine hydrochloride gives oximes in 81-95%yields in water andEtOH under ultrasound irradiation. Compared to conventional methods, the main advantages of the present procedure are milder reaction conditions, shorter reaction times and higher yields.
- Khoramabadi-Zad,Azadmanesh,Rezaee
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p. 192 - 194
(2013/01/09)
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- 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): formula (I) wherein Cy is selected from formula (Il) and wherein R1, R2, R3, Q, G, Ar, m, n and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 109
(2010/04/06)
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- 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein Q, R1, R4, m and Ar are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 126
(2009/04/25)
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- 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, R6, B, D, E, G, Q, x and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 28
(2009/01/24)
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- 6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1—R4 A, B, D, E, and G are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 51
(2008/12/08)
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- COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
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The present disclosure provides compounds having affinity for the 5HT6 receptor which are of the formula (I), wherein R1-R3 A, B, D, E, G, Q, and x are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
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Page/Page column 138-139
(2010/11/28)
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- A ratiometric fluorescent sensor for Ag1 with high selectivity and sensitivity
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A bicyclic cycloadduct 1 bearing a pyrenyl moiety has been synthesized and investigated as a ratiometric fluorescent sensor for AgI. In an aqueous ethanol solution of 1, the presence of silver ion induces the formation of a 1:2 metal-ligand complex, which exhibits a strong intensity enhancement of the pyrene excimer emission at the expense of the emission of monomeric pyrene. Copyright
- Yang, Rong-Hua,Chan, Wing-Hong,Lee, Albert W. M.,Xia, Ping-Fang,Zhang, Hong-Kui,Li, Ke'An
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p. 2884 - 2885
(2007/10/03)
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- Regioselective synthesis of syn-oximes using 3A molecular sieves in a solventless system
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Regioselective synthesis of syn-oximes using 3A molecular sieves under solvent-free condition is described.
- Bigdeli, Mohammad A.,Nikje, Mir.M.Alavi,Jafari, Said,Heravi, Majid M.
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- Chemoselective preparation of oximes, semicarbazones, and tosylhydrazones without catalyst and solvent
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A simple and versatile method for the synthesis of oximes, semicarbazones, and tosylhydrazones of aldehydes in the presence of ketones without catalyst and solvent is presented.
- Bandgar, Babasaheb P.,Sadavarte, Vaibhav S.,Uppalla, Lav S.,Govande, Rahul
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p. 403 - 406
(2007/10/03)
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- Synthesis, Structure, Electrochemistry, and Magnetism of [MnIIIMnIII], [MnIIIFeIII] and [FeIIIFeIII] Cores: Generation of Phenoxyl Radical Containing [FeIIIFeIII] Species
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Neutral homo- and heterobinuclear complexes with the general formula [(tmtacn)MA(salox)3MB] where MA (MnIII or FeIII) is facially coordinated to the cyclic amine 1,4,7-trimethyl-1,4,7-triazacyclononane (tmtacn) and MB (MnIII or FeIII) is coordinated to the azomethine nitrogens and phenolate oxygens of the bridging ligand, salicylaldoxime, thus yielding MAN3O3 and MBN3O3 cores. The compounds were characterized by IR, UV/Vis, mass spectrometry, Moessbauer spectroscopy, electrochemistry, and variable-temperature (2-295 K) magnetic susceptibility measurements. The molecular structures of the compounds [(tmtacn)FeIII(salox)3-FeIII] (3) and [(tmtacn)FeIII(tBuSalox)3FeIII] (4) were established by X-ray diffraction. Three oximate groups -HC=N-O bridge the metal centers with Fe...Fe separations of 3.571(1) and 3.486(1) Angstroem for (3) and (4), respectively. Analysis of the susceptibility data yields antiferromagnetic interactions between the metal centers for the complexes FeIIIFeIII and MnIIIFeIII, but a ferromagnetic interaction for MnIIIMnIII. The electrochemistry of all complexes was investigated in detail. For the complexes FeIIIFeIII (3) and (4) a series of reversible oneelectron transfer waves leads to the formation of the cations [Fe2]1+/2+/3+ that are attributed to the generation of saloxbased phenoxyl radicals.
- Verani, Claudio Nazari,Bothe, Eberhard,Burdinski, Dirk,Weyhermueller, Thomas,Floerke, Ulrich,Chaudhuri, Phalguni
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p. 2161 - 2170
(2007/10/03)
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- Reactivity of nitronate salts. Application to oxyme synthesis by reaction of nitronates on aromatics in acidic medium
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Nitronates salts from nitromethane and nitroethane react in acids with aromatics to yield oximes.With benzene, the reaction gives oximes (mostly the Z isomer) of benzaldehyde and acetophenone, the best yields being observed when using anhydrous hydrogen fluoride.Reaction with activated aromatics (toluene, phenol, anisole) affords the corresponding oximes, the regioselectivity being in agreement with an electrophilic aromatic substitution.The postulated mechanism implies hydroxynitrilium ions as intermediates, on which kinetically controlled addition of aromatics, gives Z-oximes.Key words: nitronates / oximes / hydroxynitrilium ions / hydrogen fluoride
- Berrier, C.,Brahmi, R.,Carreyre, H.,Coustard, J. M.,Jacquesy, J. C.,Violeau, B.
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p. 730 - 737
(2007/10/02)
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- 1H and 13C NMR Studies of some O-Carbamoyloximes
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The 1H and 13C NMR spectra were assigned for a series of O-carbamoyloximes of ortho- and para-substituted benzaldehyde.These compounds exist exclusively in the E configuration.The aromatic protons and carbons show correlations with the appropriate substituent-induced shifts and with Hammett parameters. KEY WORDS O-Carbamoyloximes 1H and 13C NMR Hammett parameters
- Wazeer, Mohammed I. M.,Ali, Sk. A.,Arab, Mohammed
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p. 1102 - 1104
(2007/10/02)
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