21013-96-7Relevant articles and documents
Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis
Ciccone, Lidia,Nencetti, Susanna,Nicolo, Tonali,Carole, Fruchart-Gaillard,William, Shepard,Elisa, Nuti,Caterina, Camodeca,Armando, Rossello,Orlandini, Elisabetta
, (2020/08/07)
Transthyretin (TTR) is a ?-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. TTR also interacts with amyloid-β, playing a protective role in Alzheimer's disease. Dissociation of the nat
Chromatography-free entry to substituted salicylonitriles: Mitsunobu-triggered domino reactions of salicylaldoximes
Whiting, Ellis,Lanning, Maryanna E.,Scheenstra, Jacob A.,Fletcher, Steven
, p. 1229 - 1234 (2015/01/30)
A mild and efficient one-pot procedure is described to transform salicylaldoximes into salicylonitriles using Mitsunobu chemistry. The reactions proceed through the corresponding 1,2-benzisoxazoles that undergo the Kemp elimination in situ to generate the
A novel and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to oximes
Yu, Jiatao,Cao, Xiaohua,Lu, Ming
supporting information, p. 5751 - 5755 (2015/02/02)
A simple and efficient catalytic system including TEMPO/acetaldoxime/InCl3 for aerobic oxidation of primary amines to corresponding oximes by using toluene as the solvent is described. This practical method can use O2 as the economic and green oxidant, tolerate a wide range of substrates, which can afford the target oximes in moderate to excellent yields.