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210181-19-4

N-tert-Butyl-3-[3(S)-[Nalpha-[2-[3-(dimethylamino)phenoxy]acetyl]-L-valylamino]-2(S)-hydroxy-4-phenylbutyryl]-5,5-dimethylthiazolidine-4(R)-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • N-tert-Butyl-3-[3(S)-[Nalpha-[2-[3-(dimethylamino)phenoxy]acetyl]-L-valylamino]-2(S)-hydroxy-4-phenylbutyryl]-5,5-dimethylthiazolidine-4(R)-carboxamide

    Cas No: 210181-19-4

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  • 210181-19-4 Structure

  • Basic information

    1. Product Name: N-tert-Butyl-3-[3(S)-[Nalpha-[2-[3-(dimethylamino)phenoxy]acetyl]-L-valylamino]-2(S)-hydroxy-4-phenylbutyryl]-5,5-dimethylthiazolidine-4(R)-carboxamide
    2. Synonyms: JE-2178
    3. CAS NO:210181-19-4
    4. Molecular Formula: C35H51N5O6S
    5. Molecular Weight: 669.89062
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 210181-19-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-tert-Butyl-3-[3(S)-[Nalpha-[2-[3-(dimethylamino)phenoxy]acetyl]-L-valylamino]-2(S)-hydroxy-4-phenylbutyryl]-5,5-dimethylthiazolidine-4(R)-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-tert-Butyl-3-[3(S)-[Nalpha-[2-[3-(dimethylamino)phenoxy]acetyl]-L-valylamino]-2(S)-hydroxy-4-phenylbutyryl]-5,5-dimethylthiazolidine-4(R)-carboxamide(210181-19-4)
    11. EPA Substance Registry System: N-tert-Butyl-3-[3(S)-[Nalpha-[2-[3-(dimethylamino)phenoxy]acetyl]-L-valylamino]-2(S)-hydroxy-4-phenylbutyryl]-5,5-dimethylthiazolidine-4(R)-carboxamide(210181-19-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 210181-19-4(Hazardous Substances Data)

210181-19-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 210181-19-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,0,1,8 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 210181-19:
(8*2)+(7*1)+(6*0)+(5*1)+(4*8)+(3*1)+(2*1)+(1*9)=74
74 % 10 = 4
So 210181-19-4 is a valid CAS Registry Number.

210181-19-4Downstream Products

210181-19-4Relevant articles and documents

Tripeptide compounds and anti-AIDS medicine

-

, (2008/06/13)

A novel tripeptide compound represented by the following general formula (I) exhibiting superior HIV protease inhibition activity, and an anti-AIDS medicine comprising this compound as an effective component and a pharmaceutically acceptable salt thereof.

Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere

Mimoto, Tsutomu,Hattori, Naoko,Takaku, Haruo,Kisanuki, Sumitsugu,Fukazawa, Tominaga,Terashima, Keisuke,Kato, Ryohei,Nojima, Satoshi,Misawa, Satoru,Ueno, Takamasa,Imai, Junya,Enomoto, Hiroshi,Tanaka, Shigeki,Sakikawa, Hiroshi,Shintani, Makoto,Hayashi, Hideya,Kiso, Yoshiaki

, p. 1310 - 1326 (2007/10/03)

We designed and synthesized a new class of peptidomimetic human immunodeficiency virus protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid], with a hydroxymethylcarbonyl isostere as the active moiety. From a structure-activity relationship study of HIV-1 protease inhibition, enzyme selectivity for other aspartyl proteases, the antiviral activity and pharmacokinetics in rats, 24c (KNI-227) and 24d (KNI-272, our first clinical candidate) were found to be selective and orally potent HIV protease inhibitors. Moreover, an improvement of the pharmacokinetic features of KNI-272 provided two long-lasting and highly bioavailable compounds (24g: JE-2178,h: JE-2179).

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