- Synthesis and evaluation of intrinsic bioactivity of fluorescein and phenolphthalein derivatives
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Fluorescein and phenolphthalein derivatives have been synthesized and screened for their bioactivity via molecular docking, cytotoxicity and antioxidant studies. In molecular docking studies, the compounds 3d have exhibited better glide score and hydrogen bonding ability when docked with t-RNA Dimethylallyltransferase. Antioxidant capabilities were evaluated via DPPH and ABTS radical scavenging activity. In this screening, compound 3d exhibited better inhibition efficiency in the DPPH and ABTS methods. Cytotoxicity of the compounds was assessed by the cell sustainability assay against human cervical cancer cell line (HeLa). All the synthesized compounds exhibited cytotoxic effects against HeLa cells and compounds 3d displayed better activity (IC50) than the standard drug (doxorubicin).
- Bharathkumar, Kuruba,Durairaj, Arulappan,Mohanapriya, Raman,Obadiah, Asir,Ramanathan, Subramanian,Santhoshkumar, Palanichamy,Vasanthkumar, Samuel
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- Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis
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Zn1-xTixO NPs were efficiently synthesized using a simple solution free mechanochemical method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn1-xTixO catalysts were positively correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodology was also extended to sulfone-fluorescein dye synthesis.
- Jadhav, Nirajkumar H.,Shinde, Dnyaneshwar R.,Sakate, Sachin S.,Rasal, Nishant K.,Pawar, Ramdas A.
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- Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives
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Polycondensation reactions of phenols with phthalic anhydride were carried out in the presence of ferric hydrogensulphate under melt conditions. The reactions proceeded in short reaction times by using a catalytic amount of Fe(HSO4)3 and the corresponding fluorescein derivatives were obtained in high yields. The simplicity, scale-up, along with the use of an inexpensive, non-toxic, recyclable catalyst of an environmentally benign nature, are other remarkable features of the procedure. The absorption and emission properties of these fluorescein derivatives were studied.
- Eshghi, Hossein,Mirzaie, Narges
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experimental part
p. 504 - 509
(2012/07/13)
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- High purity phthalein derivatives and method for preparing same
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The invention concerns high purity phthalcin derivatives enabling their use for medical applications or in the field of biotechnology, as well as their preparation method whereby a phthatic anhydride derivative is condensed with a naphthol or phenol derivative in an organic acid ester and the crystals of the resulting condensate are converted by action of a strong acid or one of its precursors in anhydrous medium.
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Page/Page column 7
(2008/06/13)
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- Solvent-free synthesis of sulfonephthaleins, sulfonefluoresceins and fluoresceins under microwave irradiation
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An efficient solvent-free synthesis of sulfonephthaleins, sulfonefluoresceins and fluoresceins under microwave irradiation is reported.
- Cihelnik, Simon,Stibor, Ivan,Lhotak, Pavel
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p. 1779 - 1789
(2007/10/03)
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