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2103-64-2

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2103-64-2 Usage

Uses

Gallein inhibits neutrophil chemotaxis and inflammation, via the disruption of G protein βγ subunit signaling.

Definition

ChEBI: A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.

Preparation

3,4,5-Trihydroxybenzoic acid or Benzene-1,2,3-triol?and Phthalic anhydride?in 190 ~ 200 ℃ reaction (namely GALLEIN), and then into sodium salt namely Alizarine Violet.

Biological Activity

Inhibitor of G protein β γ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

Properties and Applications

blue light purple. Free acid soluble in hot water for the big red, soluble in hot ethanol for red light brown. In concentrated sulfuric acid to red light yellow, after dilution with fluorescence red yellow precipitation. Dye aqueous solution to join sodium hydroxide as blue. Standard Ironing Fastness Light Fastness Fulling Persperation Fastness Soaping Water Alkali Acid ISO 4-5 4 4 5 4 5 AATCC 5 4-5 5 5 5

Standard

Ironing Fastness

Alkali

Acid

ISO

4-5

AATCC

5

Check Digit Verification of cas no

The CAS Registry Mumber 2103-64-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,0 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2103-64:
(6*2)+(5*1)+(4*0)+(3*3)+(2*6)+(1*4)=42
42 % 10 = 2
So 2103-64-2 is a valid CAS Registry Number.

2103-64-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name GALLEIN

1.2 Other means of identification

Product number -
Other names GALLIEN

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2103-64-2 SDS

2103-64-2Relevant articles and documents

Synthesis and evaluation of intrinsic bioactivity of fluorescein and phenolphthalein derivatives

Bharathkumar, Kuruba,Durairaj, Arulappan,Mohanapriya, Raman,Obadiah, Asir,Ramanathan, Subramanian,Santhoshkumar, Palanichamy,Vasanthkumar, Samuel

, (2021/09/28)

Fluorescein and phenolphthalein derivatives have been synthesized and screened for their bioactivity via molecular docking, cytotoxicity and antioxidant studies. In molecular docking studies, the compounds 3d have exhibited better glide score and hydrogen bonding ability when docked with t-RNA Dimethylallyltransferase. Antioxidant capabilities were evaluated via DPPH and ABTS radical scavenging activity. In this screening, compound 3d exhibited better inhibition efficiency in the DPPH and ABTS methods. Cytotoxicity of the compounds was assessed by the cell sustainability assay against human cervical cancer cell line (HeLa). All the synthesized compounds exhibited cytotoxic effects against HeLa cells and compounds 3d displayed better activity (IC50) than the standard drug (doxorubicin).

Ferric hydrogensulphate as a recyclable catalyst for the synthesis of fluorescein derivatives

Eshghi, Hossein,Mirzaie, Narges

experimental part, p. 504 - 509 (2012/07/13)

Polycondensation reactions of phenols with phthalic anhydride were carried out in the presence of ferric hydrogensulphate under melt conditions. The reactions proceeded in short reaction times by using a catalytic amount of Fe(HSO4)3 and the corresponding fluorescein derivatives were obtained in high yields. The simplicity, scale-up, along with the use of an inexpensive, non-toxic, recyclable catalyst of an environmentally benign nature, are other remarkable features of the procedure. The absorption and emission properties of these fluorescein derivatives were studied.

Solvent-free synthesis of sulfonephthaleins, sulfonefluoresceins and fluoresceins under microwave irradiation

Cihelnik, Simon,Stibor, Ivan,Lhotak, Pavel

, p. 1779 - 1789 (2007/10/03)

An efficient solvent-free synthesis of sulfonephthaleins, sulfonefluoresceins and fluoresceins under microwave irradiation is reported.

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