210354-17-9

Basic information

• Product Name: 4-(PYRIMIDIN-2-YL)BROMOBENZENE
• Synonyms: 2-(4-BROMOPHENYL)PYRIMIDINE;4-(PYRIMIDIN-2-YL)BROMOBENZENE;1-Bromo-4-(pyrimidin-2-yl)benzene, 2-(4-Bromophenyl)-1,3-diazine
• CAS NO: 210354-17-9
• Molecular Formula: C₁₀H₇BrN₂
• Molecular Weight: 235.08
• EINECS: 200-258-5
• Product Categories: Phenyls & Phenyl-Het;Halides;Phenyls & Phenyl-Het
• Mol File: 210354-17-9.mol

Chemical Properties

• Melting Point: 126-127 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 237.6±32.0 °C(Predicted)
• Appearance: /
• Density: 1.493±0.06 g/cm3(Predicted)
• PKA: 0.81±0.13(Predicted)
• CAS DataBase Reference: 4-(PYRIMIDIN-2-YL)BROMOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRIMIDIN-2-YL)BROMOBENZENE(210354-17-9)
• EPA Substance Registry System: 4-(PYRIMIDIN-2-YL)BROMOBENZENE(210354-17-9)

Safety Data

• Hazardous Substances Data: 210354-17-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(PYRIMIDIN-2-YL)BROMOBENZENE is used as a key intermediate in the synthesis of pharmaceutical drugs due to its ability to be incorporated into complex molecular frameworks, enhancing the development of novel therapeutic agents.
Used in Agrochemical Industry:
In agrochemical applications, 4-(PYRIMIDIN-2-YL)BROMOBENZENE is utilized as a precursor in the creation of new agrochemicals, potentially leading to the discovery of innovative solutions for pest control and crop protection.
Used in Material Science:
4-(PYRIMIDIN-2-YL)BROMOBENZENE is employed as a component in the development of new materials, leveraging its chemical properties to contribute to advancements in material properties and performance.
Used as a Reagent in Chemical Reactions:
4-(PYRIMIDIN-2-YL)BROMOBENZENE serves as a reagent in various chemical processes, facilitating specific reactions that are crucial for the synthesis of a range of chemical products.

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 851199-85-4 (pyrimidin-2-yl)boronic acid 
• 2975-46-4 3-(trimethylsilyl)prop-2-yn-1-al 
• 55368-42-8 4-bromobenzamidine hydrochloride 
• 22265-36-7 4-bromobenzamidine 
• 289-96-3 1,2,3-triazine 
• 5467-74-3 4-Bromophenylboronic acid 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 1088408-16-5 7(S)-7-deoxy-7-(4-(pyrimidin-2-yl)phenylthio)lincomycin 
• 181133-17-5 N-(3,4-Dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-pyrimidinyl)[1,1'-biphenyl]-2-sulfonamide 
• 1220526-74-8 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidine 
• 1093407-56-7 4-(4-pyrimidin-2-yl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 942190-00-3 C₁₅H₁₅N₃ 
• 942190-02-5 2-chloro-1-[4-(4-pyrimidin-2-yl-phenyl)-3,6-dihydro-2H-pyridin-1yl]-ethanone 
• 1093061-47-2 (S)-N-(3-(4-fluorophenyl)-1H-indazol-5-yl)-3-(methylthio)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)ethyl)pyrrolidine-3-carboxamide 
• 1220526-64-6 2,4-diphenyl-6-[4,4-di(2-pyrimidyl)-[1,1';3',1]-terphenyl-5'-yl]-1,3,5-triazine 
• 252019-70-8 2-(4-Triisopropylsilylsulphanylphenyl)pyrimidine 
• 545426-62-8 (2E)-3-[4-(2-Pyrimidinyl)phenyl]-2-butenoic Acid Ethyl Ester 
• 545426-66-2 2-[4-(3-furanyl)phenyl]pyrimidine 

Relevant articles and documents

Heterogeneous gold(I)-catalyzed cyclization between ynals and amidines: An efficient and practical synthesis of 2,4-disubstituted pyrimidines

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Antracene derivatives having heteroaryl substituted phenyl group and organic light-emitting diode including the same

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Organic compound, application thereof and organic light-emitting device

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Organic light-emitting diode including aryl substituted antracene derivatives

The present invention, in regards to an organic light-emitting diode comprising a luminous layer and an electron transport layer between a first electrode and a second electrode, relates to an organic light emitting diode which includes one or more anthracene derivatives selected from compounds represented by chemical formula A below in the electron transport layer, and which includes one or more anthracene derivatives selected from compounds represented by chemical formula B below in the luminous layer. L_1, L_2, Y, Z, m, and m′ below are defined in the detailed description of the present invention.

Organic light-emitting diode including aryl substituted antracene derivatives

The present invention, in regards to an organic light emitting diode comprising a luminous layer and an electron transport layer between a first electrode and a second electrode, relates to an organic light emitting diode which includes one or more anthracene derivatives selected from compounds represented by chemical formula A below in the electron transport layer, and which includes one or more anthracene derivatives selected from compounds represented by chemical formula B below in the luminous layer. L_a, L_b, A, Y and m below are defined in the detailed description of the present invention.

Inverse electron demand diels-alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope

A systematic study of the inverse electron demand Diels-Alder reactions of 1,2,3-triazines is disclosed, including an examination of the impact of a C5 substituent. Such substituents were found to exhibit a remarkable impact on the cycloaddition reactivity of the 1,2,3-triazine without altering, and perhaps even enhancing, the intrinsic cycloaddition regioselectivity. The study revealed not only that the reactivity may be predictably modulated by a C5 substituent (R = CO2Me > Ph > H) but also that the impact is of a magnitude to convert 1,2,3-triazine (1) and its modest cycloaddition scope into a heterocyclic azadiene system with a reaction scope that portends extensive synthetic utility, expanding the range of participating dienophiles. Significantly, the studies define a now powerful additional heterocyclic azadiene, complementary to the isomeric 1,2,4-triazines and 1,3,5-triazines, capable of dependable participation in inverse electron demand Diels-Alder reactions, extending the number of complementary heterocyclic ring systems accessible with implementation of the methodology.

Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine

Chemical equations presented. An examination of the scope of the inverse electron demand Diels-Alder reactions of the parent unsubstituted 1,2,3-triazine is described including the first report of its unique capabilities for participating in previously unexplored [4 + 2] cycloaddition reactions with heterodienophiles.

LINCOSAMIDE DERIVATIVE, AND ANTIBACTERIAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT

An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

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