55368-42-8

Basic information

• Product Name: 4-Bromobenzamidine hydrochloride
• Synonyms: 4-Bromo-benzamidine hydrochloride ,99%;4-broMobenzene-1-carboxiMidaMide hydrochloride;4-broMobenzaMidine hydrogen chloride;4-Bromobenzamidine Hydrochloride Hydrate;Halogenobenzamidine hydrochloride;4-BROMO-BENZAMIDINE HYDROCHLORIDE;4-bromobenzimidamide hydrochloride;4-Bromobenzimidamide, HCl
• CAS NO: 55368-42-8
• Molecular Formula: C₇H₇BrN₂*ClH
• Molecular Weight: 235.51
• Product Categories: Phenyls & Phenyl-Het;blocks;Bromides;BuildingBlocks;Carboxes;Phenyls & Phenyl-Het
• Mol File: 55368-42-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 269-272℃ ()
• Boiling Point: 260.8°C at 760 mmHg
• Flash Point: 111.5°C
• Appearance: White/Crystalline Solid
• Vapor Pressure: 0.012mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-Bromobenzamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromobenzamidine hydrochloride(55368-42-8)
• EPA Substance Registry System: 4-Bromobenzamidine hydrochloride(55368-42-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 55368-42-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

4-Bromobenzimidamide, HCl

InChI:InChI=1/C7H7BrN2.ClH/c8-6-3-1-5(2-4-6)7(9)10;/h1-4H,(H3,9,10);1H

Upstream product

• 64-17-5 ethanol 
• 55368-83-7 4-bromo-benzimidic acid ethyl ester hydrochloride 
• 19227-14-6 p-bromobenzamidoxime 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 344312-90-9 2-(p-bromophenyl)-5-nitropyrimidine 
• 150595-67-8 2-(4-Bromophenyl)-5-ethoxypyrimidine 
• 174720-35-5 2-(4-bromo-phenyl)-5-isopropyl-pyrimidine 
• 174720-39-9 2-(4-bromophenyl)-5-phenylpyrimidine 
• 1262443-67-3 2-(4-bromophenyl)-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-ol 
• 1262443-65-1 2-(4-bromophenyl)-7,7-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidin-4-ol 
• 1613637-94-7 2-(4-bromophenyl)-4-methyl-1,3,5-triazine 
• 156732-93-3 2,4-bis(4-bromophenyl)-1,3,5-triazine 
• 3164-13-4 2-(4-bromophenyl)-1,3-benzoxazole 
• 428844-82-0 2-(4-bromophenyl)-5-methylbenzo[d]oxazole 
• 1246472-13-8 5-bromo-2-(4′-bromophenyl)-1,3-benzoxazole 

Relevant articles and documents

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

A continuous flow process is presented that enables the efficient synthesis and derivatization of 1,2,4-thiadiazole heterocycles. Special attention was given to the safe handling of the versatile yet hazardous trichloromethane sulfenylchloride reagent including its in-line quenching in order to eliminate malodourous and corrosive by-products. Based on this flow method gram quantities of 5-chloro-3-phenyl-1,2,4-thiadiazole were safely prepared allowing for further elaboration of this valuable building block by reaction with different nitrogen-, sulfur- and oxygen-based nucleophiles. This synthetic approach was subsequently applied to generate a series of bromophenyl-5-chloro-1,2,4-thiadiazoles providing a valuable entry towards further structural diversification on this important heterocyclic scaffold.

Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists

Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.