55368-42-8

Basic information

• Product Name: 4-Bromobenzamidine hydrochloride
• Synonyms: 4-Bromo-benzamidine hydrochloride ,99%;4-broMobenzene-1-carboxiMidaMide hydrochloride;4-broMobenzaMidine hydrogen chloride;4-Bromobenzamidine Hydrochloride Hydrate;Halogenobenzamidine hydrochloride;4-BROMO-BENZAMIDINE HYDROCHLORIDE;4-bromobenzimidamide hydrochloride;4-Bromobenzimidamide, HCl
• CAS NO: 55368-42-8
• Molecular Formula: C₇H₇BrN₂*ClH
• Molecular Weight: 235.51
• Product Categories: Phenyls & Phenyl-Het;blocks;Bromides;BuildingBlocks;Carboxes;Phenyls & Phenyl-Het
• Mol File: 55368-42-8.mol

Chemical Properties

• Melting Point: 269-272℃ ()
• Boiling Point: 260.8°C at 760 mmHg
• Flash Point: 111.5°C
• Appearance: White/Crystalline Solid
• Vapor Pressure: 0.012mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-Bromobenzamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromobenzamidine hydrochloride(55368-42-8)
• EPA Substance Registry System: 4-Bromobenzamidine hydrochloride(55368-42-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 55368-42-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

4-Bromobenzimidamide, HCl

InChI:InChI=1/C7H7BrN2.ClH/c8-6-3-1-5(2-4-6)7(9)10;/h1-4H,(H3,9,10);1H

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 64-17-5 ethanol 
• 55368-83-7 4-bromo-benzimidic acid ethyl ester hydrochloride 
• 19227-14-6 p-bromobenzamidoxime 

Downstream Products

• 1449754-23-7 2-(4-bromophenyl)chromeno[3,2-d]imidazol-9(1H)-one 
• 55368-79-1 3,5-bis(4-bromophenyl)-1H-1,2,4-triazole 
• 457613-56-8 2-(4-bromophenyl)-4,6-diphenylpyrimidine 
• 1222094-28-1 2-(4-bromo-phenyl)-quinazoline 
• 1579511-77-5 2-(4-bromophenyl)-1,3-diazaspiro[4.4]non-1-en-4-one 
• 65004-19-5 3-(4-bromophenyl)-5-phenyl[1,2,4]oxadiazole 
• 83800-88-8 2-(4-bromophenyl)-3H-quinazolin-4-one 
• 137726-53-5 2,4-bis(4-bromophenyl)-6-phenyl-1,3,5-triazine 
• 156732-93-3 2,4-bis(4-bromophenyl)-1,3,5-triazine 

Relevant articles and documents

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

A continuous flow process is presented that enables the efficient synthesis and derivatization of 1,2,4-thiadiazole heterocycles. Special attention was given to the safe handling of the versatile yet hazardous trichloromethane sulfenylchloride reagent including its in-line quenching in order to eliminate malodourous and corrosive by-products. Based on this flow method gram quantities of 5-chloro-3-phenyl-1,2,4-thiadiazole were safely prepared allowing for further elaboration of this valuable building block by reaction with different nitrogen-, sulfur- and oxygen-based nucleophiles. This synthetic approach was subsequently applied to generate a series of bromophenyl-5-chloro-1,2,4-thiadiazoles providing a valuable entry towards further structural diversification on this important heterocyclic scaffold.

A 2 - (4 - bromophenyl) -4 - biphenyl -6 - phenyl pyrimidine synthesis method (by machine translation)

The invention belongs to the technical field of organic electroluminescent material, discloses a 2 - (4 - bromophenyl) - 4 - biphenyl - 6 - phenyl pyrimidine synthesis method, the invention organic matter to bromophenylmethyl as raw materials, preparation

AROMATIC HETEROCYCLIC COMPOUND

The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted and the like; X is a single bond and the like; Y is alkyl which may be substituted and the like; Z is CR1 or nitrogen atom; R1 is hydrogen and the like; R2 is alkyl which may be substituted and the like or a pharmaceutically acceptable salt thereof is useful as a prevention/treatment agent of obesity, diabetes, and the like.

Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists

Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.

Preparation of amidines from amidoximes via transfer hydrogenation

Amidoximes are reduced into amidine using triethyl silane and PdCl 2 in acetic acid. Copyright

Dimerization and trapping of diazirinyl radicals

Computational and experimental methods have been utilized to examine the facile dimerization of diazirinyl radicals. Two potential dimers were investigated using density functional theory. Both were shown to have low-barrier reaction coordinates leading t

Synthesis, transition temperatures and some physical properties of some low-melting smectic materials

As part of a systematic study of the factors affecting the smectic C phase, a dipole (ie., an oxygen atom) was introduced into the middle of one of the (non-polarisable) alkyl chains of a model phenylpyrimidine. A carbon-carbon double bond has also been i

Nitrogen heterocycles and liquid crystalline mixtures containing them

Compounds of the general formula STR1 wherein R1 is C5-12 -alkyl or C5-12 -alkenyl; R2 is C1-9 -alkyl or C2-9 -alkenyl; provided that at least one of groups R1 and R2

Pyrimidine derivatives and liquid crystal compositions including same

2-phenyl-5-(4'-trans-cyclohexyl) phenyl pyrimidine derivatives represented by the general formula: STR1 wherein R is a straight chain alkyl group having 1 to 10 carbon atoms; X is CN or F; Y is F or H; Z is F or H; and when X is F, at least one of Y and Z is H; and the cyclohexane ring is a trans isomer, exhibiting a nematic phase and having a high nematic phase-isotropic liquid phase transition temperature (N-I Point) and large positive dielectric constant anisotropy (Δε). The pyrimidine derivatives may be included in liquid crystal compositions for improved display devices having a wide temperature range, including a high N-I point, a low threshold voltage and a low driving voltage.