Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella aff. mirabilis
The first synthesis of tokaramide A (1) is described. Tokaramide A (1) was synthesized via the peptide with a side-chain unprotected arginine residue on Weinreb AM resin by reductive cleavage.
Konno, Hiroyuki,Nosaka, Kazuto,Akaji, Kenichi
experimental part
p. 9067 - 9071
(2011/12/01)
Total synthesis of miraziridine A and identification of its major reaction site for cathepsin B
The synthesis of miraziridine A, a pentapeptide derivative isolated from marine sponge, and its truncated analogs has been achieved. To construct the backbone of miraziridine A, a side-chain-unprotected vinylogous arginine was condensed with an aziridine-