Provided herein are novel compounds as inhibitors of type I receptor tyrosine kinases, the pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and the use of the compounds and salts thereof in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals and especially in humans.
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Page/Page column 167; 168
(2021/09/17)
Nickel-catalyzed N-arylation of benzophenone hydrazone with bromoarenes
A nickel-catalyzed method for the cross-coupling of benzophenone hydrazone with aryl bromides is described. The use of a simple Ni(ii)/NHC catalyst leads to the arylated hydrazones in good or acceptable yields. This protocol provides a simple, convenient alternative to the synthesis of arylhydrazines.
Highly reactive, general, and long-lived catalysts for coupling heteroaryl and aryl chlorides with primary nitrogen nucleophiles
Resisting pathways for decomposition followed by palladium complexes of monodentate ligands is one characteristic of the highly reactive but long-lived catalyst generated from the Josiphos ligand L and palladium. It catalyzes under mild conditions the coupling of primary amines with chloropyridines and chloroarenes in high yield with low catalyst loadings (see scheme).
Shen, Qilong,Shekhar, Shashank,Stambuli, James P.,Hartwig, John F.
p. 1371 - 1375
(2007/10/03)
A palladium-catalyzed method for the preparation of indoles via the Fischer indole synthesis
A Pd-catalyzed method for the preparation of N-aryl benzophenone hydrazones 4 is described. The use of a Pd/BINAP-based catalyst provides hydrazones 4 in good yields. Using 0.1 mol % of a Pd/9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (Xantphos) cata
Wagaw, Seble,Yang, Bryant H.,Buchwald, Stephen L.
p. 10251 - 10263
(2007/10/03)
A palladium-catalyzed strategy for the preparation of indoles: A novel entry into the Fischer indole synthesis
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Wagaw,Yang,Buchwald
p. 6621 - 6622
(2007/10/03)
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