- Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers
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A series of N-1,3-benzothiazol-2-ylbenzamide derivatives were studied for their antiproliferative activity on human liver hepatocellular carcinoma (HepG2) and human breast cancer (MCF-7) cell lines. Most of them were found to show a prominent inhibitory e
- Corbo, Filomena,Carocci, Alessia,Armenise, Domenico,De Laurentis, Nicolino,Laghezza, Antonio,Loiodice, Fulvio,Ancona, Patrizia,Muraglia, Marilena,Pagliarulo, Vincenzo,Franchini, Carlo,Catalano, Alessia
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Read Online
- BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS
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Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
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Page/Page column 688; 690
(2018/03/25)
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- Synthesis and antifungal activity against strains of Candida albicans of 6-fluoro-4(5 or 7)-chloro-2-(difluorobenzoyl)aminobenzothiazoles
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A series of 6-fluoro-4-(5 or 7)-chloro-2-(difluorobenzoyl) aminobenzothiazoles 3a-r were prepared to investigate their potential biological activity. In this work, the results of their in vitro antifungal activity against some strains of Candida albicans
- Armenise, Domenico,De Laurentis, Nicolino,Reho, Antonia,Rosato, Antonio,Morlacchi, Flaviano
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p. 771 - 775
(2007/10/03)
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- Substituted benzothiazols with herbicidal action
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Substituted benzothiazoles I and their salts STR1 used as herbicides and for the desiccation/abscission of plants.
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