211029-69-5Relevant articles and documents
Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones
Power, David P.,Lozach, Olivier,Meijer, Laurent,Grayson, David H.,Connon, Stephen J.
scheme or table, p. 4940 - 4944 (2010/10/04)
A remarkably concise, chromatography-free route to the parent compound of the paullone family of cyclin-dependent kinase (CDK) inhibitors is reported. A similar strategy allowed the synthesis of the hitherto missing 9-azapaullone and its protonated, N-oxidised and N-alkylated derivatives. Screening studies identified an active and strongly selective inhibitor of CDK9/cyclin T.
Transition metal catalyzed synthesis of 5-azaindoles
Xu, Lianhong,Lewis, Iestyn R.,Davidsen, Steven K.,Summers, James B.
, p. 5159 - 5162 (2007/10/03)
In an effort to develop synthetic procedures for the preparation of 2- substituted 5-azaindoles, the synthesis and cyclization reactions of acetylenic aminopyridines was explored. A novel method for the synthesis of 2-substituted 5-azaindoles via a transi