211430-93-2Relevant articles and documents
A systematic study on the use of different organocatalytic activation modes for asymmetric conjugated addition reactions of isoindolinones
Scorzelli, Francesco,Di Mola, Antonia,De Piano, Francesco,Tedesco, Consiglia,Palombi, Laura,Filosa, Rosanna,Waser, Mario,Massa, Antonio
, p. 819 - 828 (2017/01/28)
In this article we describe a series of new asymmetric Michael reactions of carboxylate-3-substituted isoindolinones used as nucleophiles in the synthesis of valuable chiral tetrasubstituted derivatives. It has been shown that the reactivity and enantiose
Silver-catalyzed spirolactonization: first synthesis of spiroisoindole-γ-methylene-γ-butyrolactones
Rammah, Mohamed M.,Othman, Mohamed,Ciamala, Kabula,Strohmann, Carsten,Rammah, Mohamed B.
, p. 3505 - 3516 (2008/09/21)
γ-Acetylenic carboxylic acids are cyclized to spirolactones under mild conditions, in the presence of Ag2CO3 catalyst. The corresponding spiro-5-alkylidene-γ-butyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.
Halolactonization of γ-acetylenic acids: systhesis of novel spiroisoindole halobutyrolactones
Rammah, Mohamed M.,Othman, Mohamed,Msaddek, Moncef,Rammah, Mohamed B.
scheme or table, p. 1971 - 1981 (2009/04/06)
γ-Acetylenic carboxylic acids are cyclized to spirohalo butyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding 5(E)-haloalkylidene-spirobutyrolactones were isolated in high yields, and this process constitutes an easy and efficient route to analogous structures of natural products of biological interest.
New fused lactones from indolizinediones via N-acyliminium ions
Othman, Mohamed,Pigeon, Pascal,Decroix, Bernard
, p. 8737 - 8744 (2007/10/03)
N-Arylmethylphthalimidine-3-carboxylates 3 are good precursors for the synthesis of ketones 5a,b or enols 6c-e which upon acidic treatment led to lactones 7 via an N-acyliminium ion.
