14961-34-3

Basic information

• Product Name: Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate
• Synonyms: Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate;2-Ethoxycarbonylmethyl-benzoic acid ethyl ester
• CAS NO: 14961-34-3
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.26374
• Mol File: 14961-34-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 22-23 °C
• Boiling Point: 164-169 °C(Press: 19 Torr)
• Appearance: /
• Density: 1.093 g/cm3(Temp: 25 °C)
• CAS DataBase Reference: Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate(14961-34-3)
• EPA Substance Registry System: Ethyl 2-(2-ethoxy-2-oxoethyl)benzoate(14961-34-3)

Safety Data

• Hazardous Substances Data: 14961-34-3(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 6627-91-4 2-cyanomethylbenzoic acid 
• 7647-01-0 hydrogenchloride 
• 151-50-8 potassium cyanide 
• 7115-91-5 2-ethoxycarbonylbenzyl bromide 
• 129112-26-1 2-iodophenyltrifluoromethanesulfonic acid 
• 105-53-3 diethyl malonate 
• 89-51-0 Homophthalic acid 
• 75-03-6 ethyl iodide 
• 87-41-2 2-benzofuran-1(3H)-one 
• 95-13-6 1-indene 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 437652-18-1 3,4-methylenedioxybenzylidene homophthalic acid 
• 66298-56-4 (2-carboethoxyphenyl)acetic acid 
• 86727-15-3 4-(4-methylcyclohexylidene)isochroman 
• 86727-20-0 2-(2-hydroxymethylphenyl)-2-(1-methyl-4-piperidylidene)ethanol 
• 86727-14-2 4-(4-benzylcyclohexylidene)isochroman 
• 86727-19-7 2-(1-benzyl-4-piperidylidene)-2-(2-hydroxymethylphenyl)ethanol 
• 86727-17-5 diethyl α-(1-benzyl-4-piperidylidene)homophthalate 
• 86727-18-6 diethyl α-<1-benzyl-4-(1,2,5,6-tetrahydropyridyl)>homophthalate 
• 85684-83-9 1-benzyl-4-(4-isochromanylidene)piperidine 
• 86727-23-3 1-benzyl-4-(4-isochromanyl)piperidine 
• 2289-03-4 1-oxo-1H-isochromene-3-carboxylic acid 
• 7509-13-9 1-hydroxy-isoquinoline-3-carboxylic acid 
• 1065329-91-0 N-((2,4-dichlorophenyl)methyl)-2-ethyl-3-oxo-2,3-dihydro-1H-isoindole-1-carboxamide 

Relevant articles and documents

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Aza-heterocyclic frameworks through intramolecular π-system trapping of spiro-N-acyliminiums generated from isoindolinone

Spiro-acetoxylactams as key substrates were obtained straightforwardly by the tandem regioselective reduction/O-acylation of spiro-isoindolinone-imides. The latter were produced in large scale in three steps from homophthalic acid. These imides were useful to provide in one step isoindolinones bearing hydroxymethyl-amide functions, tethered at quaternary carbon centre with promising biological issues. Submitted to Br?nsted (TFA neat) and Lewis acid (trimethylsilyltrifluoro-methanesulfonic (TMSOTf) 10 mol%), the spiro-acetoxylactams undergo π-cyclization of spiro-N-acyliminiums to provide diastereoselectively with π-aromatic original pyrrolopyrido- and pyrroloazepino-isoindoles fused or not to aromatic systems. With π-olefins, pyrrolopyridines and pyrrolo-azepines fused to isoindoline or containing amino-acids were isolated. A reaction mechanism producing all these systems is also discussed.

Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.

NEW COMPOUNDS I/418

There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.