- Peptide Tethering: Pocket-Directed Fragment Screening for Peptidomimetic Inhibitor Discovery
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Constrained peptides have proven to be a rich source of ligands for protein surfaces, but are often limited in their binding potency. Deployment of nonnatural side chains that access unoccupied crevices on the receptor surface offers a potential avenue to
- Arora, Paramjit S.,Marrone, Frank,Modell, Ashley E.,Panigrahi, Nihar R.,Zhang, Yingkai
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supporting information
p. 1198 - 1204
(2022/02/05)
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- A coordinated synthesis and conjugation strategy for the preparation of homogeneous glycoconjugate vaccine candidates
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A sweet solution: A strategy for the synthesis of well-defined carbohydrate-based vaccines is presented. The approach couples complex oligosaccharide synthesis to site-specific conjugation methodology to provide pure glycoprotein vaccine candidates (see scheme). Copyright
- Grayson, Elizabeth J.,Bernardes, Goncalo J. L.,Chalker, Justin M.,Boutureira, Omar,Koeppe, Julia R.,Davis, Benjamin G.
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supporting information; experimental part
p. 4127 - 4132
(2011/07/07)
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- Heteroaryl thioglycosides, a new class of substrates for glycosidases
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We have found that heteroaryl thioglycosides are useful substrates of β-glucosidase from almond and can act as a new class of donors in transglycosylation reaction.
- Niemiec-Cyganek,Szeja
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p. 969 - 973
(2007/10/03)
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- PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS
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The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1
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