213248-46-5Relevant articles and documents
Tandem catalysis by lipase in a vinyl acetate-mediated cross-aldol reaction
Kumar, Manjeet,Shah, Bhahwal A.,Taneja, Subhash C.
experimental part, p. 1207 - 1212 (2011/06/25)
The lipase Novozym435 (0.6% w/w) was used in tandem with organocatalysts in a first vinyl/isopropenyl acetate-mediated aldol reaction. The reaction was facilitated through the lipase-catalyzed in situ generation of acetaldehyde/acetone. The important features of the present methodology include the mild and facile reaction conditions, regenerability of the lipase, comparatively high yields and minimal side product formation.
A prodrug approach towards the development of tricyclic-based FBPase inhibitors
Tsukada, Tomoharu,Tamaki, Kazuhiko,Tanaka, Jun,Takagi, Toshiyuki,Yoshida, Taishi,Okuno, Akira,Shiiki, Takeshi,Takahashi, Mizuki,Nishi, Takahide
scheme or table, p. 2938 - 2941 (2010/08/05)
For the purpose of reducing the strong CYP3A4 inhibitory potency of diamide prodrug 4, cyclic prodrugs of tricyclic-based FBPase inhibitors were synthesized. Extensive SAR studies led to the discovery of pyridine-containing cyclic prodrug 20, which strong
NOVEL 2'-C-METHYL AND 4'-C-METHYL NUCLEOSIDE DERIVATIVES
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Page/Page column 101, (2008/06/13)
Novel 2'-C-methyl nucleoside 5 '-monophosphate and 4'-C-methyl nucleoside 5'- monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral inf
Novel 2'-C-methyl nucleoside derivatives
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Page/Page column 37, (2008/06/13)
Compounds of Formula I, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described:
Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
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Page column 162, (2010/02/07)
Pharmaceutical compositions containing an FBPase inhibitor and an insulin sensitizer are provided as well as methods for treating diabetes and diseases responding to increased glycemic control, an improvement in insulin sensitivity, a reduction in insulin levels, or an enhancement of insulin secretion.
Novel phosphonic acid based prodrugs of PMEA and its analogues
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Page 16, (2010/11/30)
Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: 1wherein: M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmet
Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase
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, (2008/06/13)
FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose or excess glycogen storage.