213627-30-6Relevant articles and documents
NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
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, (2021/01/23)
The present invention relates to inhibitors of apoptosis signal-regulating kinase 1 ("ASK1"), a process for synthesis of the compounds of the present invention, composition comprising the compounds and use of the compounds for inhibition of ASK1.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors
Fidanze, Steven D.,Liu, Dachun,Mantei, Robert A.,Hasvold, Lisa A.,Pratt, John K.,Sheppard, George S.,Wang, Le,Holms, James H.,Dai, Yujia,Aguirre, Ana,Bogdan, Andrew,Dietrich, Justin D.,Marjanovic, Jasmina,Park, Chang H.,Hutchins, Charles W.,Lin, Xiaoyu,Bui, Mai H.,Huang, Xiaoli,Wilcox, Denise,Li, Leiming,Wang, Rongqi,Kovar, Peter,Magoc, Terrance J.,Rajaraman, Ganesh,Albert, Daniel H.,Shen, Yu,Kati, Warren M.,McDaniel, Keith F.
supporting information, p. 1804 - 1810 (2018/04/23)
Novel conformationally constrained BET bromodomain inhibitors have been developed. These inhibitors were optimized in two similar, yet distinct chemical series, the 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (A) and the 1-methyl-1H-pyrrolo[2,3-c]pyridin
CATHEPSIN K INHIBITOR AND APPLICATION THEREOF
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Paragraph 0390, (2018/07/29)
The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for treating or preventing cathepsin dependent diseases or conditions, specifically, wherein the cathepsin is capthepsin K. The compounds and compositions thereof can be used as bone resorption inhibitors for the treatment of associated diseases.
BROMODOMAIN INHIBITORS
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Paragraph 0784, (2014/09/29)
The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, A1, A2, A3, and A4 have any of the values defined in the specificati
DIHYDRO-PYRROLOPYRIDINONE INHIBITORS
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Paragraph 1266, (2014/09/29)
The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
TETRACYCLIC BROMODOMAIN INHIBITORS
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Page/Page column 106, (2014/09/29)
The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Υ2, Υ3, A1, A2, A3 and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES
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Page/Page column 19, (2010/08/08)
The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
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Page/Page column 319-320, (2008/12/05)
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened or hedgehog activity.
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
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Page/Page column 319-320, (2008/12/05)
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal patched pathway or agonizing smoothened orhedgehog activity.
ACYL BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
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Page/Page column 31, (2008/12/06)
Bipiperidyl compounds of the formula: (I) are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.