213738-77-3

Basic information

• Product Name: Glycidyl PalMitoleate
• Synonyms: Glycidyl PalMitoleate;(±)-Oxiran-2-ylmethyl (9Z)-hexadec-9-enoate;(9Z)-9-Hexadecenoic acid 2-oxiranylmethyl ester;UCM710
• CAS NO: 213738-77-3
• Molecular Formula: C19H34O3
• Molecular Weight: 310.47146
• Product Categories: Aliphatics, Glycerols, Fatty Acid Derivatives & Lipids, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 213738-77-3.mol

Chemical Properties

• Boiling Point: 402.3±28.0 °C(Predicted)
• Appearance: colorless to light yellow/
• Density: 0.950±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: Glycidyl PalMitoleate(CAS DataBase Reference)
• NIST Chemistry Reference: Glycidyl PalMitoleate(213738-77-3)
• EPA Substance Registry System: Glycidyl PalMitoleate(213738-77-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 213738-77-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Glycidyl PalMitoleate is used as a therapeutic agent for its potential neuroprotective and anti-inflammatory effects. The compound's ability to inhibit α/β-hydrolase domain 6 and fatty acid amide hydrolase leads to an increase in the levels of N-arachidonoylethanolamine and 2-arachidonoylglycerol, which are known to play a role in reducing inflammation and promoting neuronal health.
Used in Neurological Applications:
Glycidyl PalMitoleate is used as a neuromodulator for its potential benefits in treating neurological disorders. The compound's action on enhancing the levels of N-arachidonoylethanolamine and 2-arachidonoylglycerol may help in alleviating symptoms associated with conditions such as anxiety, depression, and chronic pain.
Used in Cosmetic Industry:
Glycidyl PalMitoleate is used as an active ingredient in skincare products for its potential anti-aging and skin health benefits. The compound's ability to modulate the levels of N-arachidonoylethanolamine and 2-arachidonoylglycerol may contribute to improved skin hydration, reduced inflammation, and enhanced skin barrier function.
Used in Research Applications:
Glycidyl PalMitoleate is used as a research tool for studying the roles of α/β-hydrolase domain 6 and fatty acid amide hydrolase in various biological processes. The compound's dual inhibitory action allows researchers to investigate the effects of these enzymes on neuronal function and other related pathways.

Upstream product

• 373-49-9 cis-9-hexadecenoic acid 
• 556-52-5 oxiranyl-methanol 
• 40426-22-0 ( Z )-hexadec-9-enoyl chloride 

Relevant articles and documents

Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis - Comparison with effects upon fatty acid amide hydrolase

A series of 32 heterocyclic analogues based on the structure of 2-arachidonoylglycerol (2-AG) were synthesized and tested for their ability to inhibit monoacylglycerol lipase and fatty acid amide hydrolase activities. The designed compounds feature a hydrophobic moiety and different heterocyclic subunits that mimic the glycerol fragment. This series has allowed us to carry out the first systematic structure-activity relationship study on inhibition of 2-AG hydrolysis. The most promising compounds were oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (1) and tetrahydro-2H-pyran-2- ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (5). They inhibited cytosolic 2-oleoylglycerol (2-OG) hydrolysis completely (IC50 values of 4.5 and 5.6 μM, respectively). They also blocked, albeit less potently, 2-OG hydrolysis in membrane fractions (IC50 values of 19 and 26 μM, respectively) and anandamide hydrolysis (IC50 values of 12 and 51 μM, respectively). These compounds will be useful in delineating the importance of the cytosolic hydrolytic activity in the regulation of 2-AG levels and, hence, its potential as a target for drug development.

Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof

The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.