213767-22-7

Basic information

• Product Name: 2-Debenzoyl Paclitaxel 2-Pentanoate
• Synonyms: 2-Debenzoyl Paclitaxel 2-Pentanoate;(αR,βS)-β-(BenzoylaMino)-α-hydroxy-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-12-[(1-oxopentyl)oxy]-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
• CAS NO: 213767-22-7
• Molecular Formula: C45H55NO14
• Molecular Weight: 833.9165
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 213767-22-7.mol

Chemical Properties

• Boiling Point: 923.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 11.90±0.20(Predicted)
• CAS DataBase Reference: 2-Debenzoyl Paclitaxel 2-Pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Debenzoyl Paclitaxel 2-Pentanoate(213767-22-7)
• EPA Substance Registry System: 2-Debenzoyl Paclitaxel 2-Pentanoate(213767-22-7)

Safety Data

• Hazardous Substances Data: 213767-22-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Debenzoyl Paclitaxel 2-Pentanoate is used as an intermediate in the synthesis of novel Paclitaxel analogs for the development of more effective and less toxic anticancer drugs. Its improved solubility and bioavailability make it a promising candidate for enhancing the therapeutic potential of Paclitaxel in cancer treatment.
Used in Anticancer Applications:
As a Paclitaxel analog, 2-Debenzoyl Paclitaxel 2-Pentanoate is used as an anticancer agent, targeting the same cellular mechanisms as its parent compound. It is particularly effective against various solid malignancies, including breast, ovarian, lung, and pancreatic cancers. The compound works by stabilizing microtubules, inhibiting cell division, and ultimately leading to cell death.
Used in Drug Delivery Systems:
2-Debenzoyl Paclitaxel 2-Pentanoate can be used in the development of innovative drug delivery systems to improve the pharmacokinetics and biodistribution of Paclitaxel. By incorporating this analog into nanoparticles, liposomes, or other carriers, researchers can enhance the drug's solubility, bioavailability, and targeted delivery to cancer cells, potentially reducing side effects and increasing therapeutic efficacy.
Used in Research and Development:
In addition to its potential applications in the pharmaceutical industry, 2-Debenzoyl Paclitaxel 2-Pentanoate is also used as a research tool to study the structure-activity relationship of Paclitaxel and its analogs. This knowledge can be applied to design and synthesize new, more potent, and less toxic anticancer agents.

Upstream product

• 1055033-93-6 C₅₇H₈₃NO₁₄Si₂ 
• 114655-02-6 2'-O-(tert-butyldimethylsilyl)paclitaxel 
• 156413-61-5 2'-(tert-butyldimethylsilyl)-7-(triethylsilyl)paclitaxel 
• 162459-94-1 2'-(tert-butyldimethylsilyl)-2-debenzoyl-7-(triethylsilyl)paclitaxel 
• 33069-62-4 taxol 

Relevant articles and documents

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol)

The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl derivatives by three different methods. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with enhanced activity as compared with paclitaxel were discovered. Correlation of cytotoxicity in three cell lines with tubulin polymerization activity showed reasonable agreement. Among the cell lines examined, the closest correlation with antitubulin activity was observed with a human ovarian carcinoma cell line.