Basic information

Product Name: (αR,βS)-β-(BenzoylaMino)-α-tert-butyl(diMethyl)silyloxy-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4-triethylsilyloxy-11-hydroxy-4a,8,13,13-tetraMethyl-5-oxo-12-[(1-oxopentyl)oxy]-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonyms: (αR,βS)-β-(BenzoylaMino)-α-tert-butyl(diMethyl)silyloxy-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4-triethylsilyloxy-11-hydroxy-4a,8,13,13-tetraMethyl-5-oxo-12-[(1-oxopentyl)oxy]-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester;7-O-(Triethylsilyl)-2'-O-tert-butyl(diMethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate
CAS NO:1055033-93-6
Molecular Formula: C₅₇H₈₃NO₁₄Si₂
Molecular Weight: 1062.43822
EINECS: N/A
Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 1055033-93-6.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: N/A
Refractive Index: N/A
Storage Temp.: -20°C Freezer
Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
CAS DataBase Reference: (αR,βS)-β-(BenzoylaMino)-α-tert-butyl(diMethyl)silyloxy-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4-triethylsilyloxy-11-hydroxy-4a,8,13,13-tetraMethyl-5-oxo-12-[(1-oxopentyl)oxy]-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester(CAS DataBase Reference)
NIST Chemistry Reference: (αR,βS)-β-(BenzoylaMino)-α-tert-butyl(diMethyl)silyloxy-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4-triethylsilyloxy-11-hydroxy-4a,8,13,13-tetraMethyl-5-oxo-12-[(1-oxopentyl)oxy]-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester(1055033-93-6)
EPA Substance Registry System: (αR,βS)-β-(BenzoylaMino)-α-tert-butyl(diMethyl)silyloxy-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4-triethylsilyloxy-11-hydroxy-4a,8,13,13-tetraMethyl-5-oxo-12-[(1-oxopentyl)oxy]-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester(1055033-93-6)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1055033-93-6(Hazardous Substances Data)

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1055033-93-6 Usage

Chemical Properties

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Uses

Paclitaxel (Taxol) analog.

Check Digit Verification of cas no

The CAS Registry Mumber 1055033-93-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,5,0,3 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1055033-93:
(9*1)+(8*0)+(7*5)+(6*5)+(5*0)+(4*3)+(3*3)+(2*9)+(1*3)=116
116 % 10 = 6
So 1055033-93-6 is a valid CAS Registry Number.

1055033-93-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name	7-O-(Triethylsilyl)-2'-O-tert-butyl(dimethyl)silyl 2-Debenzoyl Paclitaxel 2-Pentanoate

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1055033-93-6 SDS

1055033-93-6Upstream product

1055033-93-6Downstream Products

213767-22-7 C₄₅H₅₅NO₁₄

1055033-93-6Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol)

Kingston, David G. I.,Chaudhary, Ashok G.,Chordia, Mahendra D.,Gharpure, Milind,Gunatilaka, A. A. Leslie,Higgs, Paul I.,Rimoldi, John M.,Samala, Lakshman,Jagtap, Prakash G.,Giannakakou, Paraskevi,Jiang, Yuan Q.,Lin, Chii M.,Hamel, Ernest,Long, Byron H.,Fairchild, Craig R.,Johnston, Kathy A.

, p. 3715 - 3726 (2007/10/03)

The anticancer drug paclitaxel (Taxol) has been converted to a large number of 2-debenzoyl-2-aroyl derivatives by three different methods. The bioactivities of the resulting analogues were determined in both tubulin polymerization and cytotoxicity assays, and several analogues with enhanced activity as compared with paclitaxel were discovered. Correlation of cytotoxicity in three cell lines with tubulin polymerization activity showed reasonable agreement. Among the cell lines examined, the closest correlation with antitubulin activity was observed with a human ovarian carcinoma cell line.

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