214045-82-6

Basic information

• Product Name: 5-CHLOROPYRIDO[4,3-B]PYRAZINE
• Synonyms: 5-CHLOROPYRIDO[4,3-B]PYRAZINE;Pyrido[3,4-b]pyrazine, 5-chloro-;5-Chloropyrido[3,4-b]pyrazine;5-chloropyrido[3;5-Chloropyridino[3,4-b]pyrazine
• CAS NO: 214045-82-6
• Molecular Formula: C7H4ClN3
• Molecular Weight: 165.57976
• Mol File: 214045-82-6.mol

Chemical Properties

• Boiling Point: 314.2 °C at 760 mmHg
• Flash Point: 173 °C
• Appearance: /
• Density: 1.437 g/cm³
• Vapor Pressure: 0.000872mmHg at 25°C
• Refractive Index: 1.674
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.44±0.30(Predicted)
• CAS DataBase Reference: 5-CHLOROPYRIDO[4,3-B]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROPYRIDO[4,3-B]PYRAZINE(214045-82-6)
• EPA Substance Registry System: 5-CHLOROPYRIDO[4,3-B]PYRAZINE(214045-82-6)

Safety Data

• Hazardous Substances Data: 214045-82-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLOROPYRIDO[4,3-B]PYRAZINE is used as an active ingredient in the development of new drugs. Its unique chemical properties and reactivity make it a promising candidate for the creation of innovative pharmaceutical compounds.
Used in Agrochemical Industry:
5-CHLOROPYRIDO[4,3-B]PYRAZINE is used as an active ingredient in the development of new pesticides. Its potential use in this field is due to its ability to target and control pests, thereby contributing to improved crop protection and yield.
Used as an Intermediate in Organic Synthesis:
5-CHLOROPYRIDO[4,3-B]PYRAZINE is used as an intermediate in the synthesis of various other organic compounds. Its unique structure and reactivity make it a valuable component in the creation of a wide range of chemical products, further expanding its industrial applications.

InChI:InChI=1/C7H4ClN3/c8-7-6-5(1-2-11-7)9-3-4-10-6/h1-4H

Upstream product

• 39217-08-8 2-chloropyridine-3,4-diamine 
• 517-21-5 glyoxal sodium bisulfite 
• 131543-46-9 Glyoxal 

Relevant articles and documents

Scaffold Hopping-Driven Optimization of 4-(Quinazolin-4-yl)-3,4-dihydroquinoxalin-2(1 H)-ones as Novel Tubulin Inhibitors

Scaffold hopping-driven lead optimizations were performed based on our prior lead 7-methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (2a) by C-ring expansion and isometric replacement of the A/B-ring, successively, aimed at finding new potential alternative drug candidates with different scaffold(s), high antitumor activity, and other improved properties to replace prior, once promising drug candidates that failed in further studies. Two series of new compounds 7 (a-d) and 13 (a-j) were synthesized and evaluated for antitumor activity, leading to the discovery of three highly potent compounds 13c, 13d, and 13e with different scaffolds. They exhibited similar high antitumor activity with single digital low nanomolar GI50 values (4.6-9.6 nM) in cellular assays, comparable to lead 2a, clinical drug candidate CA-4, and paclitaxel in the same assays. Further biological evaluations identified new active compounds as tubulin polymerization inhibitors targeting the colchicine binding site. Moreover, 13d showed better aqueous solubility than 2a and a similar log P value.

ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

Pyrido[3,4-b]pyrazines. A new application of 2-chloro-3,4-diaminopyridine

5-Chloropyrido[3,4-b]pyrazines were prepared from 1,2-dicarbonyl compounds and 2-chloro-3,4-diaminopyridine. Condensation of unsymmetrical glyoxals provided a mixture of two regiosiomers with 2-substituted pyrido[3,4-b]-pyrazines as the major product. The regiochemistry was unambiguously assigned by 2D-NMR experiments. C-C- and C-N coupling reactions of 5-chloro or 5-oxo intermediates afforded the corresponding C-5 or N-6 substituted derivatives.