- Toward the supramolecular cyclodextrin dimers using nucleobase pairs
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The synthesis of eleven new cyclodextrin derivatives having nucleobase moiety - thymin-1-yl, adenin-9-yl, and guanin-9-yl - is described. These two moieties are linked by different spacers, such as aminoethyl and 1,2,3-triazolyl group. Direct nucleophilic substitution and 1,3-dipolar cycloaddition were performed in good yields (13-73%) for some of the synthesized compounds. Georg Thieme Verlag Stuttgart - New York.
- Legros, Vanessa,Hamon, Florian,Violeau, Bruno,Turpin, Frederic,Djedaini-Pilard, Florence,Desire, Jerome,Len, Christophe
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Read Online
- A new method to synthesize famciclovir
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A new and efficient method has been reported for the synthesis of 2-amino-9-[4-acetoxy-3-(acetoxymethyl)butyl-1-yl]purine(famciclovir)starting from guanine. The route involves chlorination of guanine, optimized Mitsunobu reaction, coupling with diethyl malonate, hydrogenation, reduction and esterification,and the overall yield is about 29%. This method does not require any form of chromatographic purification to give pure famciclovir, and it is an industrially viable manufacturing process for this drug. The Japan Institute of Heterocyclic Chemistry.
- Luo, Lei,Chen, Guorong,Li, Yuanchao
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experimental part
p. 2803 - 2808
(2011/04/17)
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- Preparation of famciclovir and other purine derivatives
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Purine derivatives, substituted at the 9-position, are prepared from a chloro substituted purine starting material, first making an alkyl substitution at the 9-position, then forming the desired esterified side chain, reducing this and hydrogenating the resultant diol prior to addition of alkyl carbonyl groups.
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Page/Page column 4; 5
(2008/06/13)
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- A simple preparation of N-vinyl derivatives of DNA nucleobases
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1-Vinylpyrimidines and 9-vinylpurines have been prepared via selective alkylation of the heterocyclic ring with 1,2-dibromoethane (or 1,2- dibromopropanol) followed by dehydrobromination with sodium ethoxide in ethanol/DMF.
- Ciapetti, Paola,Taddei, Maurizio
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p. 11305 - 11310
(2007/10/03)
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