214201-64-6

Basic information

• Product Name: 9-(2-Bromoethyl)-6-chloro-9H-purin-2-amine
• Synonyms: 9-(2-Bromoethyl)-6-chloro-9H-purin-2-amine;9-(2-bromoethyl)-6-chloropurin-2-amine
• CAS NO: 214201-64-6
• Molecular Formula: C₇H₇BrClN₅
• Molecular Weight: 276.52098
• Mol File: 214201-64-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 501.6±60.0 °C(Predicted)
• Appearance: /
• Density: 2.09±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.87±0.10(Predicted)
• CAS DataBase Reference: 9-(2-Bromoethyl)-6-chloro-9H-purin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(2-Bromoethyl)-6-chloro-9H-purin-2-amine(214201-64-6)
• EPA Substance Registry System: 9-(2-Bromoethyl)-6-chloro-9H-purin-2-amine(214201-64-6)

Safety Data

• Hazardous Substances Data: 214201-64-6(Hazardous Substances Data)

Upstream product

• 106-93-4 ethylene dibromide 
• 10310-21-1 2-Amino-6-chloropurin 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 540-51-2 2-bromoethanol 

Downstream Products

• 104227-87-4 9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 
• 104227-86-3 6-deoxypenciclovir 
• 97845-60-8 9-<4-acetoxy-3-(acetoxymethyl)butyl>-2-amino-6-chloro-9H-purine 
• 214201-71-5 2-amino-6-ethoyxy-9-vinylchloropurine 

Relevant articles and documents

Toward the supramolecular cyclodextrin dimers using nucleobase pairs

The synthesis of eleven new cyclodextrin derivatives having nucleobase moiety - thymin-1-yl, adenin-9-yl, and guanin-9-yl - is described. These two moieties are linked by different spacers, such as aminoethyl and 1,2,3-triazolyl group. Direct nucleophilic substitution and 1,3-dipolar cycloaddition were performed in good yields (13-73%) for some of the synthesized compounds. Georg Thieme Verlag Stuttgart - New York.

Preparation of famciclovir and other purine derivatives

Purine derivatives, substituted at the 9-position, are prepared from a chloro substituted purine starting material, first making an alkyl substitution at the 9-position, then forming the desired esterified side chain, reducing this and hydrogenating the resultant diol prior to addition of alkyl carbonyl groups.