214336-99-9Relevant articles and documents
An improved synthesis of the strained pyrrolidine-5,5-translactam ring system
Borthwick, Alan D.,Crame, Andy,Exall, Anne,Mason, Andy,Pennell, Andy
, p. 3061 - 3062 (1999)
An improved synthesis of the 5-Oxo-hexahydro-pyrrolo[3,2-b]pyrrole ring system (Pyrrolidine-5,5-trans-lactam ring system) has been achieved using cyclisation of the amino ethyl ester 4 with t-butyl magnesium chloride in THF to give the translactam 5 in 78
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality
Borthwick,Crame,Ertl,Exall,Haley,Hart,Mason,Pennell,Singh,Weingarten,Woolven
, p. 1 - 18 (2007/10/03)
The stereospecific synthesis of a series of α-methylpyrrolidine-5,5-trans-lactam inhibitors of human cytomegalovirus (HCMV) protease is described. Examination of the SAR in this series has defined the size and chirality of the α-substituent, optimized the