214337-00-5Relevant academic research and scientific papers
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality
Borthwick,Crame,Ertl,Exall,Haley,Hart,Mason,Pennell,Singh,Weingarten,Woolven
, p. 1 - 18 (2007/10/03)
The stereospecific synthesis of a series of α-methylpyrrolidine-5,5-trans-lactam inhibitors of human cytomegalovirus (HCMV) protease is described. Examination of the SAR in this series has defined the size and chirality of the α-substituent, optimized the
