Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors
Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic p
Ramurthy, Savithri,Aikawa, Mina,Amiri, Payman,Costales, Abran,Hashash, Ahmad,Jansen, Johanna M.,Lin, Song,Ma, Sylvia,Renhowe, Paul A.,Shafer, Cynthia M.,Subramanian, Sharadha,Sung, Leonard,Verhagen, Joelle
supporting information; experimental part
p. 3286 - 3289
(2011/06/24)
Substituted benzazoles and methods of their use as inhibitors of Raf kinase
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
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Page 36
(2008/06/13)
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