55690-60-3Relevant articles and documents
A 5-methoxy-2-mercaptobenzothiazole method for the preparation of (by machine translation)
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Paragraph 0028; 0029, (2017/03/17)
The invention relates to a 5-methoxy-2-mercaptobenzothiazole preparation method, comprising the following steps: adding sodium sulfide aqueous solution in the reactor, 4-chloro-3-nitroanisole, carbon disulfide is added under stirring, microwave heating to 50-95°C, the reaction to the raw dematerialised, stop the reaction, cooling to room temperature, the pH of the reaction to in the fluid adds the acid 3-5, filtering, drying to obtain 5-methoxy-2-mercaptobenzothiazole. The preparation method of this invention is the synthesis of 5-methoxy-2-mercaptobenzothiazole the new route, the process is relatively simple, easy availability of raw materials, reagents for the process of operation and relatively low toxicity, and mild reaction conditions, time is short, high yield, low cost at the same time, less wastes, high content of target products, is particularly suitable for industrial production. (by machine translation)
Copper-Catalyzed Three-Component Synthesis of Benzothiazolethiones from o-Iodoanilines, Isocyanide, and Potassium Sulfide
Dang, Pan,Zeng, Weilan,Liang, Yun
supporting information, p. 34 - 37 (2015/07/28)
An efficient copper catalyzed strategy for the synthesis of a variety of benzothiazolethione derivatives has been developed. In the presence of CuCl, the three-component reaction of o-iodoanilines and K2S with p-toluenesulfonylmethyl isocyanide proceeded smoothly to obtain the corresponding benzothiazolethiones in good to excellent isolated yields. Notably, isocyanide functioned as a carbon source and K2S functioned as a sulfur source in this reaction.
Analogues of the allosteric heat shock protein 70 (Hsp70) inhibitor, MKT-077, as anti-cancer agents
Li, Xiaokai,Srinivasan, Sharan R.,Connarn, Jamie,Ahmad, Atta,Young, Zapporah T.,Kabza, Adam M.,Zuiderweg, Erik. R. P.,Sun, Duxin,Gestwicki, Jason E.
supporting information, p. 1042 - 1047 (2013/12/04)
The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. However, MKT-077 is rapidly metabolized, which limits its use as either a chemical probe or potential therapeutic. We report the synthesis and characterization of MKT-077 analogues designed for greater stability. The most potent molecules, such as 30 (JG-98), were at least 3-fold more active than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 values of 0.4 ± 0.03 and 0.7 ± 0.2 μM, respectively). The analogues modestly destabilized the chaperone clients, Akt1 and Raf1, and induced apoptosis in these cells. Further, the microsomal half-life of JG-98 was improved at least 7-fold (t1/2 = 37 min) compared to MKT-077 (t1/2 5 min). Finally, NMR titration experiments suggested that these analogues bind an allosteric site that is known to accommodate MKT-077. These studies advance MKT-077 analogues as chemical probes for studying Hsp70s roles in cancer.
A METHOXYL ACRYLIC ESTER FUNGICIDE, THE PREPARATION METHOD AND USES THEREOF
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Page/Page column 3; 4, (2011/04/24)
A methoxyl acrylic ester fungicide, the preparation method and uses thereof. The fungicide contains at less the following compound of formula (I) as active ingredient. The fungicide can be further prepared to form the emulsifier oil by mixing with the emulsifier, latent solvent, stabilizer, and solvent. The fungicide is useful for preventing and controlling powdery mildew, downy mildew, gray mold and tan discase of vegetable, melon and fruit, discase of vegetable, melon and fruit cased by Phoma citricarpa, leaf spot of maize, false smut, blossom-end rot of orange and Sclerotinia rot of colza et al. The fungicide has many advantages such as be effect to the strain which produced the resistance, high effect, less toxic and environmrnt-friendly.
METHOXYACRYLATE-BASED FUNGICIDE AND METHODS FOR PREPARING AND USING THE SAME
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Page/Page column 2; 3, (2010/12/18)
A pharmaceutical composition of fungicide including at least a compound represented by Formula (I). The pharmaceutical composition of fungicide can further include an emulsifier, a cosolvent, a stabilizer, and a solvent. The fungicide can prevent and treat powdery mildew, downy mildew, gray mold, brown spot, scab of vegetables and fruits, southern leaf blight of corn, rice false smut, citrus stem-end rot, and rape sclerotinia rot, with high efficiency, low toxicity, and relative environmental friendliness. A method of preparing the fungicide and a method of using thereof are also provided.
Improved synthesis of 2-(3H)benzothiazolethiones under microwave irradiation
Huang, Wei,Tan, Ying,Ding, Ming-Wu,Yang, Guang-Fu
, p. 369 - 376 (2007/10/03)
2-(3H)Benzothiazolethiones (2-mercaptobenzothiazole) are prepared by an improved method, which utilizes microwave-assisted cyclization of the corresponding ortho-haloanlines with potassium O-ethyl dithiocarbonate. By using microwave irradiation, the relative reactivity of 2-chloroanilines was greatly improved to the same level as that of 2-fluoroanilines and 2-bromoanilines. Copyright Taylor & Francis Group, LLC.
Heterocyclic compounds
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, (2008/06/13)
The invention provides compounds of formula (I) having nematicidal, insecticidal, acaricidal and fungicidal properties, compositions comprising them and processes and intermediates for their preparation: STR1 wherein: X is oxygen or sulphur; n is 0, 1 or 2; R1, R2, R3, and R4 are as described in the specification.
5-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
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, (2008/06/13)
5-Hydroxy-2-benzothiazolesulfonamide is useful for the topical treatment of elevated intraocular pressure. Ophthalmic compositions including drops and inserts are disclosed.
