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AKOS B028995, also known as methoxyacetyl fentanyl, is a potent synthetic opioid analgesic drug with the molecular formula C16H23NO2. It acts as an agonist at the μ-opioid receptor and is a synthetic analogue of fentanyl, distinguished by a methoxy group attached to the piperidine ring. This modification results in a unique pharmacological profile, making it highly potent and associated with numerous overdose deaths and adverse effects. Due to its potential for abuse and health risks, AKOS B028995 is a controlled substance in many countries and is subject to strict regulations.

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  • 215124-03-1 Structure
  • Basic information

    1. Product Name: AKOS B028995
    2. Synonyms: 5-Chloro-2-hydroxy-3-iodobenzaldehyde 97%;CHEMBRDG-BB 6448206;AKOS B028995;5-CHLORO-2-HYDROXY-3-IODOBENZALDEHYDE;5-chloro-2-hydroxy-3-iodobenzaldehyde(SALTDATA: FREE);5-Chloro-3-iodo-2-hydroxybenzaldehyde;5-Chloro-3-iodosalicylaldehyde
    3. CAS NO:215124-03-1
    4. Molecular Formula: C7H4ClIO2
    5. Molecular Weight: 282.46
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 215124-03-1.mol
  • Chemical Properties

    1. Melting Point: 87-92°C
    2. Boiling Point: 245.9°C at 760 mmHg
    3. Flash Point: 102.5°C
    4. Appearance: /
    5. Density: 2.114g/cm3
    6. Vapor Pressure: 0.0179mmHg at 25°C
    7. Refractive Index: 1.718
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: AKOS B028995(CAS DataBase Reference)
    11. NIST Chemistry Reference: AKOS B028995(215124-03-1)
    12. EPA Substance Registry System: AKOS B028995(215124-03-1)
  • Safety Data

    1. Hazard Codes: T
    2. Statements: 25-36
    3. Safety Statements: 26-45
    4. RIDADR: UN 2811 6.1 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 215124-03-1(Hazardous Substances Data)

215124-03-1 Usage

Uses

Used in Pharmaceutical Industry:
AKOS B028995 is used as a potent opioid analgesic for the management of severe pain. Its high potency and affinity for the μ-opioid receptor make it effective in providing rapid and strong pain relief. However, due to its potential for abuse and adverse effects, it is strictly regulated and prescribed under close medical supervision.
Used in Research and Development:
AKOS B028995 serves as a valuable research tool in the study of opioid receptors and their role in pain management. It helps scientists understand the mechanisms of action and develop new drugs with improved safety profiles and reduced potential for abuse.

Check Digit Verification of cas no

The CAS Registry Mumber 215124-03-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,1,2 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 215124-03:
(8*2)+(7*1)+(6*5)+(5*1)+(4*2)+(3*4)+(2*0)+(1*3)=81
81 % 10 = 1
So 215124-03-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClIO2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H

215124-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-chloro-2-hydroxy-3-iodobenzaldehyde

1.2 Other means of identification

Product number -
Other names 5-chloro-2-hydroxy-3-iodo-benzaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:215124-03-1 SDS

215124-03-1Relevant articles and documents

A Novel Synthesis of 2-Ferrocenoyl-Substituted Iodobenzofurans

Li, Yang,Zhuoma, Bairenqing,Gao, Wentao

, p. 764 - 768 (2017/02/03)

In the present investigation, the first construction of a series of structurally new 2-ferrocenoyl-substituted iodobenzofurans hybrids has been achieved through a simple and mild two-step procedure, involving the iodination of salicylaldehydes using N-iodosuccinimide reagent in eco-friendly PEG-400 medium at room temperature followed by one-pot Rap–Stoermer reaction with 1-chloroacetylferrocene in refluxing MeCN with the presence of K2CO3as base and PEG-400 as the activated additive. These newly synthesized compounds belong to a new class of ferrocene-benzofuran hybrids and could be good candidates for the development of compounds for use in medicinal chemistry.

FUSED 9-MEMBERED RING DERIVATIVES HAVING AUTOTAXIN INHIBITORY ACTIVITY

-

Paragraph 0123, (2017/01/02)

PROBLEM TO BE SOLVED: To provide novel compounds having an autotaxin inhibitory effect. SOLUTION: A compound is represented by a formula in the figure, where each symbol is as defined in the specification. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandI

A simple and efficient method for solvent-free iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid by grinding method

Vibhute, Archana,Mokle, Shyam,Karamunge, Khushal,Gurav, Vasant,Vibhute, Yeshwant

experimental part, p. 914 - 918 (2011/11/12)

Green, mild and efficient iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid in the solid-state by grinding under solvent-free conditions at room temperature. This method provides several advantages such as environmentally friendly, short reaction times, high yields, non-hazardous and simple work-up procedure.

A practical iodination of aromatic compounds by using iodine and iodic acid

Shinde, Avinash T.,Zangade, Sainath B.,Chavan, Shivaji B.,Vibhute, Archana Y.,Nalwar, Yogesh S.,Vibhute, Yeshwant B.

experimental part, p. 3506 - 3513 (2011/02/22)

This article describes simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no need of catalyst, short reaction time, simple practical procedure, giving excellent yield of the product. Copyright Taylor & Francis Group, LLC.

Pyridinium lodochloride: An efficient reagent for lodination of hydroxylated aromatic ketones and aldehydes

Khansole, Sandeep V.,Mokle, Shyam S.,Sayyed, Mudassar A.,Vibhute, Yeshwant B.

experimental part, p. 871 - 874 (2009/12/01)

Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.

BENZOFURAN COMPOUNDS

-

Page/Page column 38, (2008/12/08)

A compound of formula (I), wherein R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in

(Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors

-

Page/Page column 22, (2010/02/11)

The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.

Heterocyclic glycyl β-alanine derivatives

-

, (2008/06/13)

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the αvβ3integrin.

ανβ3 integrin antagonists in combination with chemotherapeutic agents

-

, (2008/06/13)

The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.

Chiral-β-amino acid compounds and derivatives thereof

-

, (2008/06/13)

The present invention is directed to a method for the preparation of a chiral β-amino ester of the formula wherein R is lower alkyl; and X and Y are the same or different Cl, Br or I.

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