215124-03-1Relevant articles and documents
A Novel Synthesis of 2-Ferrocenoyl-Substituted Iodobenzofurans
Li, Yang,Zhuoma, Bairenqing,Gao, Wentao
, p. 764 - 768 (2017/02/03)
In the present investigation, the first construction of a series of structurally new 2-ferrocenoyl-substituted iodobenzofurans hybrids has been achieved through a simple and mild two-step procedure, involving the iodination of salicylaldehydes using N-iodosuccinimide reagent in eco-friendly PEG-400 medium at room temperature followed by one-pot Rap–Stoermer reaction with 1-chloroacetylferrocene in refluxing MeCN with the presence of K2CO3as base and PEG-400 as the activated additive. These newly synthesized compounds belong to a new class of ferrocene-benzofuran hybrids and could be good candidates for the development of compounds for use in medicinal chemistry.
FUSED 9-MEMBERED RING DERIVATIVES HAVING AUTOTAXIN INHIBITORY ACTIVITY
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Paragraph 0123, (2017/01/02)
PROBLEM TO BE SOLVED: To provide novel compounds having an autotaxin inhibitory effect. SOLUTION: A compound is represented by a formula in the figure, where each symbol is as defined in the specification. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandI
A simple and efficient method for solvent-free iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid by grinding method
Vibhute, Archana,Mokle, Shyam,Karamunge, Khushal,Gurav, Vasant,Vibhute, Yeshwant
experimental part, p. 914 - 918 (2011/11/12)
Green, mild and efficient iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid in the solid-state by grinding under solvent-free conditions at room temperature. This method provides several advantages such as environmentally friendly, short reaction times, high yields, non-hazardous and simple work-up procedure.
A practical iodination of aromatic compounds by using iodine and iodic acid
Shinde, Avinash T.,Zangade, Sainath B.,Chavan, Shivaji B.,Vibhute, Archana Y.,Nalwar, Yogesh S.,Vibhute, Yeshwant B.
experimental part, p. 3506 - 3513 (2011/02/22)
This article describes simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no need of catalyst, short reaction time, simple practical procedure, giving excellent yield of the product. Copyright Taylor & Francis Group, LLC.
Pyridinium lodochloride: An efficient reagent for lodination of hydroxylated aromatic ketones and aldehydes
Khansole, Sandeep V.,Mokle, Shyam S.,Sayyed, Mudassar A.,Vibhute, Yeshwant B.
experimental part, p. 871 - 874 (2009/12/01)
Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.
BENZOFURAN COMPOUNDS
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Page/Page column 38, (2008/12/08)
A compound of formula (I), wherein R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in
(Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors
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Page/Page column 22, (2010/02/11)
The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.
Heterocyclic glycyl β-alanine derivatives
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, (2008/06/13)
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the αvβ3integrin.
ανβ3 integrin antagonists in combination with chemotherapeutic agents
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, (2008/06/13)
The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.
Chiral-β-amino acid compounds and derivatives thereof
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, (2008/06/13)
The present invention is directed to a method for the preparation of a chiral β-amino ester of the formula wherein R is lower alkyl; and X and Y are the same or different Cl, Br or I.