71643-66-8

Basic information

• Product Name: 4-Chloro-2-iodophenol
• Synonyms: 4-CHLORO-2-IODOPHENOL;2-Iodo-4-chlorophenol;Phenol, 4-chloro-2-iodo-
• CAS NO: 71643-66-8
• Molecular Formula: C₆H₄ClIO
• Molecular Weight: 254.45
• Product Categories: Halides;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 71643-66-8.mol
• Article Data: 54

Chemical Properties

• Melting Point: 75.0 to 79.0 °C
• Boiling Point: 225.1 °C at 760 mmHg
• Flash Point: 89.9 °C
• Appearance: /
• Density: 2.087 g/cm³
• Vapor Pressure: 0.059mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Chloro-2-iodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-iodophenol(71643-66-8)
• EPA Substance Registry System: 4-Chloro-2-iodophenol(71643-66-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 71643-66-8(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-iodophenol is a chemical compound with the formula C6H4ClIO. It has a molecular weight of 248.45 g/mol and appears as a white to slightly yellow solid. 4-Chloro-2-iodophenol is often used as an intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. It is also utilized in the production of dyes and other specialty chemicals. 4-Chloro-2-iodophenol is a versatile building block with potential applications in various fields of chemistry and industry. However, it should be handled with care due to its potential health and environmental hazards.

InChI:InChI=1/C6H4ClIO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H

Upstream product

• 106-48-9 4-chloro-phenol 
• 533-58-4 2-Iodophenol 
• 132905-91-0 Isopropyl-carbamic acid 4-chloro-phenyl ester 
• 52807-27-9 4-chloro-2-iodo-1-methoxybenzene 
• 95-85-2 2-hydroxy-5-chloro-aniline 

Downstream Products

• 135062-07-6 1-(3-Bromo-propoxy)-4-chloro-2-iodo-benzene 
• 13589-72-5 5-chloro-2-hydroxybenzonitrile 
• 183589-01-7 4-chloro-2-iodophenyl acetate 
• 198902-28-2 2-(acetyloxy)-5-chlorobenzonitrile 
• 187273-03-6 3-cyano-5-chloro-2-hydroxyacetophenone 
• 187273-05-8 5-chloro-2-hydroxy-3-(5-tetrazolyl)-acetophenone 
• 187272-85-1 5'-chloro-3'-cyano-2'-hydroxy-3-[2-(2-quinolinyl)ethenyl]chalcone 
• 864750-43-6 4-Bromo-2-(4-chloro-2-iodo-phenoxymethyl)-benzonitrile 
• 215124-03-1 5-chloro-3-iodosalicylaldehyde 
• 18761-36-9 5-chloro-2-phenylbenzofuran 
• 1133247-02-5 5-chloro-2,2-bis(4-fluorophenyl)-3-(2,2,3,3-tetramethylcyclopropylidene)-2,3-dihydrobenzofuran 
• 1133246-98-6 5-chloro-2-(4-fluorophenyl)-3-(2,2,3,3-tetramethylcyclopropylidene)-2,3-dihydrobenzofuran 
• 1133246-94-2 5-chloro-2,2-diphenyl-3-(2,2,3,3-tetramethylcyclopropylidene)-2,3-dihydrobenzofuran 
• 1049011-48-4 C₁₄H₁₁ClO₂ 

Relevant articles and documents

Biomimetic carbene cascades enabled imine derivative migration from carbene -bearing thiocarbamates

Inspired by the body circulation of Omeprazole (irreversible proton pump inhibitor), we disclose the carbene-triggered cascades for the synthesis of 2-aminobenzofuran derivatives from N-sulfonyl-1,2,3-triazoles or benzothioazole-bearing thiocarbamates, which represents an unprecedented imine derivative migration process. Furthermore, the desulfurizing reagent-free Barton-Kellogg-type reactions starting from N-sulfonyl-1,2,3-triazoles have also been achieved for the first time, and elemental sulfur is confirmed as a byproduct during this transformation. Both experimental data and DFT calculations further thoroughly explained the unique reactivity.

Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Oxyacylation of Iodoalkynes: Gold(I)-Catalyzed Expeditious Access to Benzofurans

(Acetonitrile)[1,3-bis(2,6-diisopropylphenyl)-imidazole-2-ylidene] gold(I) catalyzes the cycloisomerization of 2-(iodoethynyl)aryl esters to give 3-iodo-2-acyl benzofurans. This catalytic transformation is the result of an unprecedented selective syntheti