Combined C-H functionalization/C-N bond formation route to carbazoles
A new method in which a series of substituted carbazoles is efficiently produced by the combination of an amide and an arene is described. The key feature of this method is the palladium-catalyzed tandem directed C-H functionalization and amide arylation. The method tolerates substitution on either ring of the biaryl amide substrates, and the products can be assembled in a simple two-step protocol from readily available reagents. The Pd(0) species generated are reoxidized to Pd(II) in the presence of Cu(OAc)2 and an atmosphere of oxygen. Copyright
Tsang, W. C. Peter,Zheng, Nan,Buchwald, Stephen L.
p. 14560 - 14561
(2007/10/03)
The oxidative bromination and iodination of dimethylacetanilides
The oxidative bromination and iodination of the six dimethylacetanilides have been examined; whereas bromination of 2,4-dimethyl- and 2,6-dimethylacetanilides using potassium bromide, sodium tungstate and peracetic acid gave predominantly the 6- and 4-bro
Medina, Inmaculada C. Rodriguez,Hanson, James R.
p. 428 - 429
(2007/10/03)
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