New α-substituted succinate-based hydroxamic acids as TNFα convertase inhibitors
Tumor necrosis factor α convertase (TACE), the enzyme responsible for the processing of proTNFα to TNFα, has been reported to be a metalloproteinase closely related to matrix metalloproteinases (MMPs). Current inhibitors of TACE such as succinate-based hy
Barlaam, Bernard,Bird, T. Geoffrey,Lambert-Van Der Brempt, Christine,Campbell, Douglas,Foster, Steve J.,Maciewicz, Rose
p. 4890 - 4908
(2007/10/03)
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