215606-70-5Relevant articles and documents
New α-substituted succinate-based hydroxamic acids as TNFα convertase inhibitors
Barlaam, Bernard,Bird, T. Geoffrey,Lambert-Van Der Brempt, Christine,Campbell, Douglas,Foster, Steve J.,Maciewicz, Rose
, p. 4890 - 4908 (2007/10/03)
Tumor necrosis factor α convertase (TACE), the enzyme responsible for the processing of proTNFα to TNFα, has been reported to be a metalloproteinase closely related to matrix metalloproteinases (MMPs). Current inhibitors of TACE such as succinate-based hy