- Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids
-
An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.
- Wang, Xiu-Zhi,Zeng, Cheng-Chu
-
-
Read Online
- Tetrabutylammonium Bromide-Catalyzed Transfer Hydrogenation of Quinoxaline with HBpin as a Hydrogen Source
-
A metal-free environmentally benign, simple, and efficient transfer hydrogenation process of quinoxaline has been developed using the HBpin reagent as a hydrogen source. This reaction is compatible with a variety of quinoxalines offering the desired tetrahydroquinoxalines in moderate-to-excellent yields with Bu4NBr as a noncorrosive and low-cost catalyst.
- Chen, Jingchao,Fan, Baomin,Guo, Qi,Lu, Guangfu,Shen, Guoli,Tang, Yan,Wu, Shiyuan,Yang, Xuemei,Zhu, Yuanbin
-
-
- Fluorinated Quinoxalines: Synthesis and Alkylation
-
6,7-Difluoro- and 6-fluoro-7-morpholino(4-methylpiperazinyl, 2,6-dimethylpiperazinyl)quinoxalines have been synthesized from aromatic diamines and glyoxal, and their alkylation with Meerwein reagent has been studied. A procedure has been developed for preparation of pure 1-ethylquinoxalinium salts whose structure has been confirmed by 1H NMR spectra and X-ray analysis.
- Mokrushina,Charushin,Shevelin,Chasovskikh,Shcherbakov,Aleksandrov,Chupakhin
-
p. 109 - 114
(2007/10/03)
-