Tetrahedron p. 1425 - 1430 (2019)
Update date:2022-08-03
Topics: Radical reaction Iron Catalysis Activation of α-keto acid Termination
Wang, Xiu-Zhi
Zeng, Cheng-Chu
An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.
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Doi:10.1016/s0020-1693(97)06063-5
(1998)Doi:10.1021/ja982172q
(1998)Doi:10.1021/jm4006324
(2013)Doi:10.1016/S0020-1693(98)00215-1
(1998)Doi:10.1021/ic50027a013
(1965)Doi:10.1021/jo00184a022
(1984)